Impact of time to reperfusion after acute myocardial infarction on myocardial damage assessed by left ventricular longitudinal strain

Bertini, Matteo, Mollema, Sjoerd A., Delgado, Victoria, Antoni, M. Louisa, Ng, Arnold C. T., Holman, Eduard R., Boriani, Giuseppe, Schalij, Martin J. and Bax, Jeroen J. (2009) Impact of time to reperfusion after acute myocardial infarction on myocardial damage assessed by left ventricular longitudinal strain. American Journal of Cardiology, 104 4: 480-485. doi:10.1016/j.amjcard.2009.04.010


Author Bertini, Matteo
Mollema, Sjoerd A.
Delgado, Victoria
Antoni, M. Louisa
Ng, Arnold C. T.
Holman, Eduard R.
Boriani, Giuseppe
Schalij, Martin J.
Bax, Jeroen J.
Title Impact of time to reperfusion after acute myocardial infarction on myocardial damage assessed by left ventricular longitudinal strain
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
1879-1913
Publication date 2009-08-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.amjcard.2009.04.010
Open Access Status Not yet assessed
Volume 104
Issue 4
Start page 480
End page 485
Total pages 6
Place of publication Bridgewater, NJ, United States
Publisher Excerpta Medica
Language eng
Abstract The relation between cardiac troponin T (cTnT) and regional strain in patients with acute myocardial infarction (AMI) was investigated. Furthermore, the effect of symptoms-to-balloon time on impairment in regional strain after AMI was evaluated. A total of 157 consecutive patients with AMI who underwent primary percutaneous coronary intervention were included. Two-dimensional echocardiography soon after percutaneous coronary intervention was performed. Speckle-tracking analysis was applied to assess left ventricular global and regional longitudinal peak systolic strain (LPSS). Infarcted area was defined based on the culprit vessel. Mean left ventricular ejection fraction was 47 ± 7%. Global LPSS was -14.4 ± 3.2%. The infarcted area LPSS was significantly decreased compared with global LPSS (-11.3 ± 4.5%, p <0.001). The major reflector of cTnT was infarcted area LPSS (beta 0.47, p <0.001). Mean symptoms-to-balloon time was 212 ± 92 minutes. Based on this time, the study population was divided in tertiles. In the group with the shortest symptoms-to-balloon time, global LPSS and infarcted area LPSS were less impaired compared with groups with longer symptoms-to-balloon time (p <0.01 for the 2 comparisons). In conclusion, myocardial strain was related to peak levels of cTnT, thus reflecting damage after AMI. Early reperfusion resulted in decreased myocardial damage in the infarcted area as quantified with strain.
Keyword Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
CARDIAC & CARDIOVASCULAR SYSTEMS
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 15 Apr 2013, 10:08:25 EST by Dr Chin Tse Arnold Ng on behalf of Examinations