Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects

Frank, Thomas, Netzel, Gabriele, Kammerer, Dietmar R., Carle, Reinhold, Kler, Adolf, Kriesl, Erwin, Bitsch, Irmgard, Bitsch, Roland and Netzel, Michael (2012) Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects. Journal of The Science of Food And Agriculture, 92 10: 2207-2218. doi:10.1002/jsfa.5615

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Author Frank, Thomas
Netzel, Gabriele
Kammerer, Dietmar R.
Carle, Reinhold
Kler, Adolf
Kriesl, Erwin
Bitsch, Irmgard
Bitsch, Roland
Netzel, Michael
Title Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects
Formatted title
Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects
Journal name Journal of The Science of Food And Agriculture   Check publisher's open access policy
ISSN 0022-5142
1097-0010
Publication date 2012-08-12
Sub-type Article (original research)
DOI 10.1002/jsfa.5615
Volume 92
Issue 10
Start page 2207
End page 2218
Total pages 12
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2013
Language eng
Formatted abstract
BACKGROUND: To evaluate health benefits attributed to Hibiscus sabdariffa L. a randomized, open-label, two-way crossover study was undertaken to compare the impact of an aqueous H. sabdariffa L. extract (HSE) on the systemic antioxidant potential (AOP; assayed by ferric reducing antioxidant power (FRAP)) with a reference treatment (water) in eight healthy volunteers. The biokinetic variables were the areas under the curve (AUC) of plasma FRAP, ascorbic acid and urate that are above the pre-dose concentration, and the amounts excreted into urine within 24 h (Ae0–24) of antioxidants as assayed by FRAP, ascorbic acid, uric acid, malondialdehyde (biomarker for oxidative stress), and hippuric acid (metabolite and potential biomarker for total polyphenol intake).
RESULTS: HSE caused significantly higher plasma AUC of FRAP, an increase in Ae0–24 of FRAP, ascorbic acid and hippuric acid, whereas malondialdehyde excretion was reduced. Furthermore, the main hibiscus anthocyanins as well as one glucuronide conjugate could be quantified in the volunteers' urine (0.02% of the administered dose).
CONCLUSION: The aqueous HSE investigated in this study enhanced the systemic AOP and reduced the oxidative stress in humans. Furthermore, the increased urinary hippuric acid excretion after HSE consumption indicates a high biotransformation of the ingested HSE polyphenols, most likely caused by the colonic microbiota.
Keyword Hibiscus sabdariffa L.
Polyphenols
Antioxidant potential
Malondialdehyde
Hippuric acid
Humans
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 15 Apr 2013, 03:15:48 EST by Michael Netzel on behalf of Qld Alliance for Agriculture and Food Innovation