Surface plasmon resonance biosensors for highly sensitive detection in real samples

Sepulveda, B., Carrascosa, L. G., Regatos, D., Otte, M. A., Farina, D. and Lechuga, L. M. (2009). Surface plasmon resonance biosensors for highly sensitive detection in real samples. In: Manijeh Razeghi and Hooman Mohseni, Biosensing II. Conference on Biosensing II, San Diego, United States, (73970Y.1-73970Y.11). 4-6 August 2009. doi:10.1117/12.827062

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Author Sepulveda, B.
Carrascosa, L. G.
Regatos, D.
Otte, M. A.
Farina, D.
Lechuga, L. M.
Title of paper Surface plasmon resonance biosensors for highly sensitive detection in real samples
Conference name Conference on Biosensing II
Conference location San Diego, United States
Conference dates 4-6 August 2009
Proceedings title Biosensing II   Check publisher's open access policy
Journal name Proceedings of SPIE - International Society for Optical Engineering   Check publisher's open access policy
Place of Publication Bellingham, WA, United States
Publisher S P I E - International Society for Optical Engineering
Publication Year 2009
Sub-type Fully published paper
DOI 10.1117/12.827062
Open Access Status File (Publisher version)
ISBN 9780819476876
ISSN 0277-786X
Editor Manijeh Razeghi
Hooman Mohseni
Volume 7397
Start page 73970Y.1
End page 73970Y.11
Total pages 11
Language eng
Abstract/Summary In this work we summarize the main results obtained with the portable surface plasmon resonance (SPR) device developed in our group (commercialised by SENSIA, SL, Spain), highlighting its applicability for the real-time detection of extremely low concentrations of toxic pesticides in environmental water samples. In addition, we show applications in clinical diagnosis as, on the one hand, the real-time and label-free detection of DNA hybridization and single point mutations at the gene BRCA-1, related to the predisposition in women to develop an inherited breast cancer and, on the other hand, the analysis of protein biomarkers in biological samples (urine, serum) for early detection of diseases. Despite the large number of applications already proven, the SPR technology has two main drawbacks: (i) not enough sensitivity for some specific applications (where pM-fM or single-molecule detection are needed) (ii) low multiplexing capabilities. In order solve such drawbacks, we work in several alternative configurations as the Magneto-optical Surface Plasmon Resonance sensor (MOSPR) based on a combination of magnetooptical and ferromagnetic materials, to improve the SPR sensitivity, or the Localized Surface Plasmon Resonance (LSPR) based on nanostructures (nanoparticles, nanoholes,...), for higher multiplexing capabilities.
Keyword Surface plasmon resonance
DNA detection
Protein biosensing
Magneto-optic SPR
Localized surface plasmon resonance
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
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