Haemocompatibility of Ti-3Zr-2Sn-3Mo-25Nb biomedical alloy with surface heparinization using electrostatic self assembly technology

Yu, Sen, Yu, Zhen-tao, Han, Jian-ye, Wang, Gui, Niu, Jin-long and Dargusch, Matthew S. (2012) Haemocompatibility of Ti-3Zr-2Sn-3Mo-25Nb biomedical alloy with surface heparinization using electrostatic self assembly technology. Transactions of Nonferrous Metals Society of China, 22 12: 3046-3052. doi:10.1016/S1003-6326(11)61569-0


Author Yu, Sen
Yu, Zhen-tao
Han, Jian-ye
Wang, Gui
Niu, Jin-long
Dargusch, Matthew S.
Title Haemocompatibility of Ti-3Zr-2Sn-3Mo-25Nb biomedical alloy with surface heparinization using electrostatic self assembly technology
Journal name Transactions of Nonferrous Metals Society of China   Check publisher's open access policy
ISSN 1003-6326
2210-3384
Publication date 2012-12-01
Sub-type Article (original research)
DOI 10.1016/S1003-6326(11)61569-0
Volume 22
Issue 12
Start page 3046
End page 3052
Total pages 7
Place of publication Changsha, China
Publisher Nonferrous Metals Society of China
Collection year 2013
Language eng
Abstract The haemocompatibility of Ti-3Zr-2Sn-3Mo-25Nb biomedical alloy was studied after surface heparinization. A layer of sol-gel TiO2 films was applied on the alloy samples followed by active treatment in the bio-functionalized solution for introducing the OH- and NH - 2 groups, and then the heparin was immobilized on the active TiO2 films through the electrostatic self assembly technology. It is shown that the heparinized films are mainly composed of anatase and rutile with smooth and dense surface. In vitro blood compatibility was evaluated by haemolysis test, clotting time and platelet adhesion behavior tests. The results show that the haemocompatibility of the alloy could be significantly improved by surface heparinization.
Keyword Electrostatic self assembly
Haemocompatibility
Heparinization
Surface modification
Ti-3Zr-2Sn-3Mo-25Nb alloy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mechanical & Mining Engineering Publications
Official 2013 Collection
 
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Created: Tue, 09 Apr 2013, 23:38:34 EST by Brianne Mackinnon on behalf of School of Mechanical and Mining Engineering