Re-considering how particle size and other properties of antigen-adjuvant complexes impact on the immune responses

Yan, Shiyu, Gu, Wenyi and Xu, Zhi Ping (2013) Re-considering how particle size and other properties of antigen-adjuvant complexes impact on the immune responses. Journal of Colloid and Interface Science, 395 1: 1-10. doi:10.1016/j.jcis.2012.11.061


Author Yan, Shiyu
Gu, Wenyi
Xu, Zhi Ping
Title Re-considering how particle size and other properties of antigen-adjuvant complexes impact on the immune responses
Journal name Journal of Colloid and Interface Science   Check publisher's open access policy
ISSN 0021-9797
1095-7103
Publication date 2013-04-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.jcis.2012.11.061
Open Access Status Not yet assessed
Volume 395
Issue 1
Start page 1
End page 10
Total pages 10
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Subject 2504 Electronic, Optical and Magnetic Materials
2502 Biomaterials
2508 Surfaces, Coatings and Films
1505 Colloid and Surface Chemistry
Abstract Understanding the influences of particle properties of antigen-adjuvant complexes on immunity is crucial in designing highly active adjuvants for new-generation of vaccines. This paper briefly revisits the current opinions on the size-dependent immunity of various adjuvant particles and then comprehensively discusses a few immunity-determining processes that are affected by the antigen-adjuvant particle properties. These include particle size, surface charge, surface hydrophilicity/lipophilicity, and antigen-adjuvant binding strength. Based on current understandings, we hypothesize that a maximum immune response occurs at a certain antigen-adjuvant particle size. This hypothesis clearly explains the paradoxical opinions on the size-dependent immunity and has also been supported by the data reported by several research groups. Finally, we further hypothesize that there is a similar relationship between any immune response and any measureable antigen-adjuvant particle property, and that there is a maximum immune response when all measureable antigen-adjuvant particle properties are optimized. We believe more attention should be paid to this issue when designing and developing effective adjuvants in future research.
Keyword Vaccine
Antigen
Adjuvant
Immune responses
Particle property-immunity relationship
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 12 December 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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