pH-responsive nutraceutical-mesoporous silica nanoconjugates with enhanced colloidal stability

Guillet-Nicolas, Remy, Popat, Amirali, Bridot, Jean-Luc, Monteith, Gregory, Qiao, Shi Zhang and Kleitz, Freddy (2013) pH-responsive nutraceutical-mesoporous silica nanoconjugates with enhanced colloidal stability. Angewandte Chemie International Edition, 52 8: 2318-2322. doi:10.1002/anie.201208840


Author Guillet-Nicolas, Remy
Popat, Amirali
Bridot, Jean-Luc
Monteith, Gregory
Qiao, Shi Zhang
Kleitz, Freddy
Title pH-responsive nutraceutical-mesoporous silica nanoconjugates with enhanced colloidal stability
Journal name Angewandte Chemie International Edition   Check publisher's open access policy
ISSN 1433-7851
1521-3773
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1002/anie.201208840
Open Access Status Not Open Access
Volume 52
Issue 8
Start page 2318
End page 2322
Total pages 5
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag
Language eng
Abstract An innovative platform for targeted oral drug delivery is proposed based on the functionalization of drug/dye-loaded mesoporous silica nanoparticles (MSNs) with a biodegradable nutraceutical (β-lactoglobulin). The attachment of the nutraceutical not only protects the drug/dye from leaching in acidic environment, but also effectively allows their release in desired basic sites (pH 7.4).
Keyword β-lactoglobulin
Colloidal stability
Mesoporous silica
Nutraceutical
Oral drug delivery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Pharmacy Publications
Australian Institute for Bioengineering and Nanotechnology Publications
 
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