A new role for mucins in immunity: insights from gastrointestinal nematode infection

Hasnain, Sumaira Z., Gaagher, Amanda L., Grencis, Richard K. and Thornton, David J. (2013) A new role for mucins in immunity: insights from gastrointestinal nematode infection. International Journal of Biochemistry and Cell Biology, 45 2: 364-374. doi:10.1016/j.biocel.2012.10.011


Author Hasnain, Sumaira Z.
Gaagher, Amanda L.
Grencis, Richard K.
Thornton, David J.
Title A new role for mucins in immunity: insights from gastrointestinal nematode infection
Journal name International Journal of Biochemistry and Cell Biology   Check publisher's open access policy
ISSN 1357-2725; 878-5875
Publication date 2013-02-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.biocel.2012.10.011
Open Access Status Not yet assessed
Volume 45
Issue 2
Start page 364
End page 374
Total pages 11
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 1303 Biochemistry
1307 Cell Biology
Abstract The body's mucosal surfaces are protected from pathogens and physical and chemical attack by the gel-like extracellular matrix, mucus. The framework of this barrier is provided by polymeric, gel-forming mucins. These enormous O-linked glycoproteins are synthesised, stored and secreted by goblet cells that are also the source of other protective factors. Immune regulation of goblet cells during the course of infection impacts on mucin production and properties and ultimately upon barrier function. The barrier function of mucins in protection of the host is well accepted as an important aspect of innate defence. However, it is becoming increasingly clear that mucins have a much more direct role in combating pathogens and parasites and are an important part of the coordinated immune response to infection. Of particular relevance to this review is the finding that mucins are essential anti-parasitic effector molecules. The current understanding of the roles of these multifunctional glycoproteins, and other goblet cell products, in mucosal defence against intestinal dwelling nematodes is discussed.
Keyword Mucus
Mucin
Muc2
Trichuris muris
Goblet cell
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID WT094757
Institutional Status UQ
Additional Notes Published online 27 October 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Medicine Publications
 
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