Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza

Gong, Yumei, Zhang, Peijun, Sun, Huling, Wang, Hongjun, Zhu, Wenge, He, Yunxia, Shao, Qinghong and Blackall, Patrick (2012). Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza. In: IVVDC 2012: 6th International Veterinary Vaccines and Diagnostics Conference, Cairns, Australia, (3-7). 29 July - 1 August 2012. doi:10.1016/j.vetimm.2013.01.015


Author Gong, Yumei
Zhang, Peijun
Sun, Huling
Wang, Hongjun
Zhu, Wenge
He, Yunxia
Shao, Qinghong
Blackall, Patrick
Title of paper Safety and efficacy studies on trivalent inactivated vaccines against infectious coryza
Conference name IVVDC 2012: 6th International Veterinary Vaccines and Diagnostics Conference
Conference location Cairns, Australia
Conference dates 29 July - 1 August 2012
Journal name Veterinary Immunology and Immunopathology   Check publisher's open access policy
Publication Year 2012
Sub-type Article (original research)
DOI 10.1016/j.vetimm.2013.01.015
Open Access Status Not yet assessed
ISSN 0165-2427
Volume 158
Issue 1-2
Start page 3
End page 7
Total pages 5
Language eng
Abstract/Summary The safety and efficacy of an inactivated oil-emulsion infectious coryza vaccine containing three Avibacterium paragallinarum isolates (one each of Page serovars A, B, and C) was evaluated. The safety of six batches of the vaccine was confirmed by testing with chickens vaccinated with a single large dose or vaccinated repeatedly with a normal dose. Efficacy tests were carried out on three batches of vaccine using both specific pathogen free (SPF) chickens and conventional chickens. In SPF chickens given a single vaccination at 42 days of age, the protection rate against all three serovars of Avibacterium paragallinarum was at least 80% at 30 days post vaccination. The conventional chickens, which were immunized at 42 and 110 days of age, were challenged at nine months post the second vaccination and the protection rate was at least 80% for all three serovars. The effect of storage on the vaccine was evaluated in SPF chickens using three batches of vaccine stored at 4-8 ℃ for one year. The protection rate against challenge from all three serovars (single vaccination at 42 days of age and challenge at 30 days post-vaccination) was at least 80%.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
 
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Created: Tue, 19 Mar 2013, 06:43:08 EST by Dr Patrick Blackall on behalf of Centre for Animal Science