Caveolae as plasma membrane sensors, protectors and organizers

Parton, Robert G. and del Pozo, Miguel A. (2013) Caveolae as plasma membrane sensors, protectors and organizers. Nature Reviews Molecular Cell Biology, 14 2: 98-112. doi:10.1038/nrm3512

Author Parton, Robert G.
del Pozo, Miguel A.
Title Caveolae as plasma membrane sensors, protectors and organizers
Journal name Nature Reviews Molecular Cell Biology   Check publisher's open access policy
ISSN 1471-0072
Publication date 2013-02-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrm3512
Open Access Status DOI
Volume 14
Issue 2
Start page 98
End page 112
Total pages 15
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1312 Molecular Biology
1307 Cell Biology
Abstract Caveolae are submicroscopic, plasma membrane pits that are abundant in many mammalian cell types. The past few years have seen a quantum leap in our understanding of the formation, dynamics and functions of these enigmatic structures. Caveolae have now emerged as vital plasma membrane sensors that can respond to plasma membrane stresses and remodel the extracellular environment. Caveolae at the plasma membrane can be removed by endocytosis to regulate their surface density or can be disassembled and their structural components degraded. Coat proteins, called cavins, work together with caveolins to regulate the formation of caveolae but also have the potential to dynamically transmit signals that originate in caveolae to various cellular destinations. The importance of caveolae as protective elements in the plasma membrane, and as membrane organizers and sensors, is highlighted by links between caveolae dysfunction and human diseases, including muscular dystrophies and cancer.
Keyword Congenital generalized lipodystrophy
Deprivation response gene
Transcript-release factor
Dominant-negative mutant
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID SAF2011-25047
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
Centre for Microscopy and Microanalysis Publications
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Citation counts: TR Web of Science Citation Count  Cited 306 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 316 times in Scopus Article | Citations
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