A surface based approach for cortical thickness comparison between PiB plus and PiB- Healthy Control subjects

Dore, Vincent, Bourgeat, Pierrick, Fripp, Jurgen, Acosta, Oscar, Chetelat, Gael, Szoeke, Cassandra, Ellis, Kathryn A., Martins, Ralph N., Villemagne, Victor, Masters, Colin L., Ames, David, Rowe, Christopher C. and Salvado, Olivier (2012). A surface based approach for cortical thickness comparison between PiB plus and PiB- Healthy Control subjects. In: David R. Haynor and Sebastien Ourselin, Medical Imaging 2012: Image Processing. Conference on Medical Imaging - Image Processing, San Diego Ca, (831413-1-831413-6). 6-9 February 2012. doi:10.1117/12.911752

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Author Dore, Vincent
Bourgeat, Pierrick
Fripp, Jurgen
Acosta, Oscar
Chetelat, Gael
Szoeke, Cassandra
Ellis, Kathryn A.
Martins, Ralph N.
Villemagne, Victor
Masters, Colin L.
Ames, David
Rowe, Christopher C.
Salvado, Olivier
Title of paper A surface based approach for cortical thickness comparison between PiB plus and PiB- Healthy Control subjects
Conference name Conference on Medical Imaging - Image Processing
Conference location San Diego Ca
Conference dates 6-9 February 2012
Proceedings title Medical Imaging 2012: Image Processing   Check publisher's open access policy
Journal name Proceedings of SPIE - International Society for Optical Engineering   Check publisher's open access policy
Place of Publication Bellingham, WA United States
Publisher S P I E - International Society for Optical Engineering
Publication Year 2012
Year available 2012
Sub-type Fully published paper
DOI 10.1117/12.911752
Open Access Status Not yet assessed
ISBN 9780819489630
ISSN 0277-786X
1996-756X
Editor David R. Haynor
Sebastien Ourselin
Volume 8314
Start page 831413-1
End page 831413-6
Total pages 6
Language eng
Abstract/Summary beta-amyloid has been shown to play a crucial role in Alzheimer's disease (AD). In vivo beta-amyloid imaging using [11C]Pittsburgh compound. (PiB) positron emission tomography has made it possible to analyze the relationship between beta-amyloid deposition and different pathological markers involved in AD. PiB allows us to stratify the population between subjects which are likely to have prodromal AD, and those who don't. The comparison of the cortical thickness in these different groups is important to better understanding and detect the first symptoms of the disease which may lead to an earlier therapeutic care to reduce neurone loss.
Formatted Abstract/Summary
β-amyloid has been shown to play a crucial role in Alzheimer's disease (AD). In vivo β-amyloid imaging using [11C]Pittsburgh compound Β (PiB) positron emission tomography has made it possible to analyze the relationship between β-amyloid deposition and different pathological markers involved in AD. PiB allows us to stratify the population between subjects which are likely to have prodromal AD, and those who don't. The comparison of the cortical thickness in these different groups is important to better understanding and detect the first symptoms of the disease which may lead to an earlier therapeutic care to reduce neurone loss. Several techniques have been developed to compare the cortical volume and/or thickness between AD and HC groups. However due to the noise introduced by the cortical thickness estimation and by the registration, these methods do not allow to unveil any major different when comparing prodromal AD groups with healthy control subjects group. To improve our understanding of where initial Alzheimer neurodegeneration occurs in the cortex we have developed a surface based technique, and have applied it to the discrimination between PIB-positive and PiB-negative HCs. We first identify the regions where AD patients show high cortical atrophy by using an AD/PiB- HC vertex-wise T-test. In each of these discriminating regions, comparison between PiB+ HC, PiB- HC and AD are performed. We found some significant differences between the two HC groups in the hippocampus and in the temporal lobe for both hemisphere and in the precuneus and occipital regions only for the left hemisphere.
Keyword Surface based Approach
Statistical Population Analysis
Cortical thickness
beta amyloid
Alzheimers Disease
Segmentation
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Sub-type: Fully published paper
Collections: UQ Centre for Clinical Research Publications
Non HERDC
 
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