The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

Ellis, Kathryn A., Bush, Ashley I., Darby, David, De Fazio, Daniela, Foster, Jonathan, Hudson, Peter, Lautenschlager, Nicola I., Lenzo, Nat, Martins, Ralph N., Maruff, Paul, Masters, Colin, Milner, Andrew, Pike, Kerryn, Rowe, Christopher, Savage, Greg, Szoeke, Cassandra, Taddei, Kevin, Villemagne, Victor, Woodward, Michael, Ames, David, AIBL Research Group and Salvado, Olivier (2009) The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. International Psychogeriatrics, 21 4: 672-687. doi:10.1017/S1041610209009405


Author Ellis, Kathryn A.
Bush, Ashley I.
Darby, David
De Fazio, Daniela
Foster, Jonathan
Hudson, Peter
Lautenschlager, Nicola I.
Lenzo, Nat
Martins, Ralph N.
Maruff, Paul
Masters, Colin
Milner, Andrew
Pike, Kerryn
Rowe, Christopher
Savage, Greg
Szoeke, Cassandra
Taddei, Kevin
Villemagne, Victor
Woodward, Michael
Ames, David
AIBL Research Group
Salvado, Olivier
Title The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease
Journal name International Psychogeriatrics   Check publisher's open access policy
ISSN 1041-6102
1741-203X
Publication date 2009-08-01
Year available 2009
Sub-type Article (original research)
DOI 10.1017/S1041610209009405
Open Access Status Not yet assessed
Volume 21
Issue 4
Start page 672
End page 687
Total pages 16
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Abstract Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants.
Formatted abstract
Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants.

Methods: Volunteers underwent a screening interview, had comprehensive cognitive testing, gave 80 ml of blood, and completed health and lifestyle questionnaires. One quarter of the sample also underwent amyloid PET brain imaging with Pittsburgh compound B (PiB PET) and MRI brain imaging, and a subgroup of 10% had ActiGraph activity monitoring and body composition scanning.

Results: A total of 1166 volunteers were recruited, 54 of whom were excluded from further study due to comorbid disorders which could affect cognition or because of withdrawal of consent. Participants with AD (211) had neuropsychological profiles which were consistent with AD, and were more impaired than participants with mild cognitive impairment (133) or healthy controls (768), who performed within expected norms for age on neuropsychological testing. PiB PET scans were performed on 287 participants, 100 had DEXA scans and 91 participated in ActiGraph monitoring.

Conclusion: The participants comprising the AIBL cohort represent a group of highly motivated and well-characterized individuals who represent a unique resource for the study of AD. They will be reassessed at 18-month intervals in order to determine the predictive utility of various biomarkers, cognitive parameters and lifestyle factors as indicators of AD, and as predictors of future cognitive decline.
Keyword Alzheimer's disease
Mild cognitive impairment
Healthy controls
Cohort study
Longitudinal study
PiB PET imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Information Technology and Electrical Engineering Publications
 
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