The therapeutic potential of endogenous hippocampal stem cells for the treatment of neurological disorders

Taylor, Chanel J., Jhaveri, Dhanisha J. and Bartlett, Perry F. (2013) The therapeutic potential of endogenous hippocampal stem cells for the treatment of neurological disorders. Frontiers in Cellular Neuroscience, 7 JANUARY 2013: 5.1-5.7. doi:10.3389/fncel.2013.00005

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ292231_fulltext.pdf Full text (open access) application/pdf 270.03KB 0

Author Taylor, Chanel J.
Jhaveri, Dhanisha J.
Bartlett, Perry F.
Title The therapeutic potential of endogenous hippocampal stem cells for the treatment of neurological disorders
Journal name Frontiers in Cellular Neuroscience   Check publisher's open access policy
ISSN 1662-5102
Publication date 2013-01-28
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fncel.2013.00005
Open Access Status DOI
Volume 7
Issue JANUARY 2013
Start page 5.1
End page 5.7
Total pages 7
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2014
Language eng
Abstract While it is now well established that resident populations of stem and progenitor cells drive neurogenesis in the adult brain, a growing body of evidence indicates that these new neurons play a pivotal role in spatial learning, memory and mood regulation. As such, interest is gathering to develop strategies to harness the brain's endogenous reservoir of stem and progenitor cells, with the view that newborn neurons may help overcome the loss of neural and cognitive function that occurs during neurodegenerative disease and psychiatric illness. Here we review evidence for the presence of endogenous stem cell populations in the adult hippocampus, especially large pools of latent stem and precursor cells, and the ways in which these populations can be stimulated to produce new neurons. While the translation of this research from animal models to human application is still in its infancy, understanding in detail the cellular and molecular mechanisms that regulate endogenous neurogenesis, offers the potential to use this innate reservoir of precursors to produce neurons that may be able to mitigate against cognitive decline and mood disorders.
Keyword Hippocampus
Neural stem cell
Neural precursor cell
Stem cell therapy
Endogenous adult neurogenesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article 5

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 24 Feb 2013, 11:11:30 EST by System User on behalf of Queensland Brain Institute