Prognostic value of biochemical liver parameters in neonatal sepsis-associated cholestasis

Oswari, Hanifah, Widjaja, Ruth Karisma, Rohsiswatmo, Rinawati and Cleghorn, Geoffrey (2013) Prognostic value of biochemical liver parameters in neonatal sepsis-associated cholestasis. Journal of Paediatrics and Child Health, 49 1: E6-E11. doi:10.1111/jpc.12053

Author Oswari, Hanifah
Widjaja, Ruth Karisma
Rohsiswatmo, Rinawati
Cleghorn, Geoffrey
Title Prognostic value of biochemical liver parameters in neonatal sepsis-associated cholestasis
Journal name Journal of Paediatrics and Child Health   Check publisher's open access policy
ISSN 1034-4810
Publication date 2013-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1111/jpc.12053
Volume 49
Issue 1
Start page E6
End page E11
Total pages 6
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Aims The aim of the study was to evaluate the significance of total bilirubin, aspartate transaminase (AST), alanine transaminase and gamma-glutamyltransferase (GGT) for predicting outcome in sepsis-associated cholestasis.

Methods: A retrospective cohort review of the hospital records was performed in 181 neonates admitted to the Neonatal Care Unit. A comparison was performed between subjects with low and high liver values based on cut-off values from ROC analysis. We defined poor prognosis to be when a subject had prolonged cholestasis of more than 3.5 months, developed severe sepsis, septic shock or had a fatal outcome.

The majority of the subjects were male (56%), preterm (56%) and had early onset sepsis (73%). The poor prognosis group had lower initial values of GGT compared with the good prognosis group (P = 0.003). Serum GGT (cut-off value of 85.5 U/L) and AST (cut-off value of 51 U/L) showed significant correlation with the outcome following multivariate analysis. The odds ratio (OR) of low GGT and high AST were OR 4.3 (95% CI:1.6 to11.8) and OR 2.9 (95% CI:1.1 to 8), respectively, for poor prognosis. In subjects with normal AST values, those with low GGT value had relative risk of 2.52 (95% CI:1.4 to 3.5) for poorer prognosis compared with those with normal or high GGT.

Serum GGT and AST values can be used to predict the prognosis of patients with sepsis-associated cholestasis
Keyword Ast
Sepsis associated cholestasis
Gamma Glutamyltransferase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 21 DEC 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
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