Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats

Turner, Karly M., Young, Jared W., McGrath, John J., Eyles, Darryl W. and Burne, Thomas H. J. (2013) Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats. Behavioural Brain Research, 242 1: 47-53. doi:10.1016/j.bbr.2012.12.029

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Author Turner, Karly M.
Young, Jared W.
McGrath, John J.
Eyles, Darryl W.
Burne, Thomas H. J.
Title Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 1872-7549
Publication date 2013-04-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbr.2012.12.029
Open Access Status File (Author Post-print)
Volume 242
Issue 1
Start page 47
End page 53
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 2802 Behavioral Neuroscience
Abstract Evidence from epidemiological studies suggest that low levels of vitamin D during early life alter brain development and may increase the risk of various adverse health outcomes, including schizophrenia. The aim of this experiment was to examine the effect of developmental vitamin D (DVD) deficiency on attentional processing using the 5-choice serial reaction time task (5C-SRT) and the 5-choice continuous performance test (5C-CPT), which specifically assesses sustained attention and vigilance in rodents. DVD-deficient and control rats were exposed to a series of target and non-target trials within each operant testing session. A number of measures were recorded including hit, miss, false alarm and correct rejection, as well as premature and perseverative responses. Performance on 5C-CPT was also assessed after administration of the atypical antipsychotic, clozapine. The adult offspring of DVD-deficient rats had higher levels of impulsivity, as demonstrated by a significant increase in premature responses. On the 5C-SRT and target trials of the 5C-CPT, accuracy was not significantly affected by prenatal diet; however DVD-deficient rats made 50% fewer correct rejections compared to controls on non-target trials of the 5C-CPT. Thus, control rats were able to discriminate between target and non-target trials, whereas DVD-deficient rats were unable to make this discrimination. Clozapine reduced the occurrence of false alarms in DVD-deficient rats to a level comparable to control values. Taken together these data suggest DVD-deficient rats have increased impulsivity as well as a lack of inhibitory control, and these features may be informative in terms of modeling the cognitive deficits observed in schizophrenia.
Keyword Animal model
Vitamin D
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 511066
Institutional Status UQ
Additional Notes Available online: 27 December 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 13 Feb 2013, 02:45:33 EST by Debra McMurtrie on behalf of Queensland Brain Institute