The IGF1 pathway genes and their association with age of puberty in cattle

Fortes, Marina R. S., Li, Yutao, Collis, Eliza, Zhang, Yuandan and Hawken, Rachel J. (2013) The IGF1 pathway genes and their association with age of puberty in cattle. Animal Genetics, 44 1: 91-95. doi:10.1111/j.1365-2052.2012.02367.x

Author Fortes, Marina R. S.
Li, Yutao
Collis, Eliza
Zhang, Yuandan
Hawken, Rachel J.
Title The IGF1 pathway genes and their association with age of puberty in cattle
Journal name Animal Genetics   Check publisher's open access policy
ISSN 0268-9146
Publication date 2013-02-01
Year available 2012
Sub-type Article (original research)
DOI 10.1111/j.1365-2052.2012.02367.x
Volume 44
Issue 1
Start page 91
End page 95
Total pages 5
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Insulin-like growth factor I (somatomedin C) (IGF1) influences gonadotrophin-releasing hormone (GnRH) neurons during puberty, and GnRH release guides pubertal development. Therefore, genes of the IGF1 pathway are biological candidates for the identification of single-nucleotide polymorphisms (SNPs) affecting age of puberty. In a genome-wide association study, genotyped heifers were Tropical Composite (TCOMP, n = 866) or Brahman (BRAH, n = 843), with observation of age at first corpus luteum defining puberty. We examined SNPs in or near genes of the IGF1 pathway and report seven genes associated with age at puberty in cattle: IGF1R, IGFBP2, IGFBP4, PERK (HUGO symbol EIF2AK3), PIK3R1, GSK3B and IRS1. SNPs in the IGF1 receptor (IGF1R) showed the most promising associations: two SNPs were associated with puberty in TCOMP (P < 0.05) and one in BRAH (P = 0.00009). This last SNP explained 2% of the genetic variation (R2 = 2.04%) for age of puberty in BRAH. Hence, IGF1R was examined further. Additional SNPs were genotyped, and haplotypes were analysed. To test more SNPs in this gene, four new SNPs from dbSNP were selected and genotyped. Single SNP and haploytpe analysis revealed associations with age of puberty in both breeds. There were two haplotypes of 12 IGF1R SNPs associated with puberty in BRAH (P < 0.05) and one in TCOMP (P < 0.05). One haplotype of two SNPs was associated (P < 0.01) with puberty in BRAH, but not in TCOMP. In conclusion, the IGF1 pathway appeared more relevant for age of puberty in Brahman cattle, and IGF1R showed higher significance when compared with other genes from the pathway.
Keyword IGF1 pathway
Bos taurus
Bos indicus
SNP association
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 4 May 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Veterinary Science Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sun, 10 Feb 2013, 11:25:43 EST by System User on behalf of School of Veterinary Science