The Metabolism and Excretion of Oestradiol-3-Beta-D-Glucuronide in Rats

Hollingworth, S and Pass, MA (1988) The Metabolism and Excretion of Oestradiol-3-Beta-D-Glucuronide in Rats. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology, 90 1: 99-101. doi:10.1016/0305-0491(88)90043-0


Author Hollingworth, S
Pass, MA
Title The Metabolism and Excretion of Oestradiol-3-Beta-D-Glucuronide in Rats
Journal name Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology   Check publisher's open access policy
ISSN 0305-0491
Publication date 1988-01-01
Year available 1988
Sub-type Article (original research)
DOI 10.1016/0305-0491(88)90043-0
Open Access Status Not yet assessed
Volume 90
Issue 1
Start page 99
End page 101
Total pages 3
Place of publication OXFORD
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Subject 2700 Medicine
Abstract 1. 1. Tritium labelled oestradiol-3β-d-glucuronide (E-3G) was synthesised by sodium borohydride reduction of labelled oestrone-glucuronide (E-G) and injected intravenously into anaesthetised rats. Bile and urine were collected to assess the routes and rate of excretion of E-3G. Bile and urine samples were analysed by reverse phase HPLC to determine the metabolites of E-3G. 2. 2. When E-3G was given at 11 and 22 μmol/kg, 83 and 85% respectively was excreted in bile within 3 hr and 1 and 3% in urine. 3. 3. The major metabolite was E-G which accounted for 89 and 92% respectively of the injected E-3G which was recovered in bile. 4. 4. It is concluded that bile is the major route of excretion of E-3G in rats and that it is converted mainly to E-G before excretion.
Keyword Biochemistry & Molecular Biology
Zoology
Biochemistry & Molecular Biology
Zoology
BIOCHEMISTRY & MOLECULAR BIOLOGY
ZOOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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