Effect of vitamin D deficiency during pregnancy on offspring bone structure, composition and quality in later life

Lanham, S. A., Roberts, C., Habgood, A. K., Alexander, S., Burne, T. H. J., Eyles, D. W., Trueman, C. N., Cooper, M., McGrath, J. J. and Oreffo, R. O. C. (2013) Effect of vitamin D deficiency during pregnancy on offspring bone structure, composition and quality in later life. Journal of Developmental Origins of Health and Disease, 4 1: 49-55. doi:10.1017/S2040174412000542


Author Lanham, S. A.
Roberts, C.
Habgood, A. K.
Alexander, S.
Burne, T. H. J.
Eyles, D. W.
Trueman, C. N.
Cooper, M.
McGrath, J. J.
Oreffo, R. O. C.
Title Effect of vitamin D deficiency during pregnancy on offspring bone structure, composition and quality in later life
Journal name Journal of Developmental Origins of Health and Disease   Check publisher's open access policy
ISSN 2040-1744
2040-1752
Publication date 2013-02-01
Year available 2012
Sub-type Article (original research)
DOI 10.1017/S2040174412000542
Open Access Status Not Open Access
Volume 4
Issue 1
Start page 49
End page 55
Total pages 7
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Abstract During foetal development, calcium requirements are met as a consequence of maternal adaptations independent of vitamin D status. In contrast, after birth, dependency on vitamin D appears necessary for calcium metabolism and skeletal health. We used a rodent model (Sprague-Dawley rats), to determine if maternal vitamin D deficiency during pregnancy had a deleterious effect on bone structure at birth. Vitamin D deplete females were maintained under deplete conditions until birth of the pups, whereupon all dams were fed a vitamin D replete diet. Offspring were harvested at birth, and 140 days of age. Bones were analyzed using micro-computed tomography and strength tested to study differences in bone structure, density and strength and subjected to elemental analysis using plasma mass spectrometry to determine strontium, barium and calcium contents. Offspring from deplete mothers displayed altered trabecular parameters in the femur at birth and 140 days of age. In addition, at 140 days of age there was evidence of premature mineralization of the secondary ossification centre of the femoral head. Elemental analysis showed increased strontium uptake in the femur of the developmentally vitamin D-deficient offspring. Vitamin D depletion during development in the offspring may have a long-lasting effect, despite repletion of vitamin D from birth. This may have consequences for human health given the low vitamin D levels seen during pregnancy and current lifestyle of sun avoidance due to the risk of skin cancer.
Keyword In utero
Micro-computed tomography
Strontium
Structure
Vitamin D
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 26 July 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
 
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