Effect of vehicles on the maximum transepidermal flux of similar size phenolic compounds

Zhang, Qian, Li, Peng, Liu, David and Roberts, Michael S. (2013) Effect of vehicles on the maximum transepidermal flux of similar size phenolic compounds. Pharmaceutical Research, 30 1: 32-40. doi:10.1007/s11095-012-0846-x


Author Zhang, Qian
Li, Peng
Liu, David
Roberts, Michael S.
Title Effect of vehicles on the maximum transepidermal flux of similar size phenolic compounds
Journal name Pharmaceutical Research   Check publisher's open access policy
ISSN 0724-8741
1573-904X
Publication date 2013-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s11095-012-0846-x
Open Access Status Not Open Access
Volume 30
Issue 1
Start page 32
End page 40
Total pages 9
Place of publication New York, NY, United States
Publisher Springer New York LLC
Language eng
Formatted abstract
Purpose: In principle, maximum transepidermal fluxes of solutes should be similar for different vehicles, except when the solute or vehicle modifies the skin. Here we estimated maximum flux, stratum corneum solubility, diffusivity and permeability coefficient for a range of similarly sized phenolic compounds with varying lipophilicity from polar and lipophilic vehicles.
Methods: Maximum flux and other skin transport parameters through human epidermis were obtained from lipophilic vehicles (mineral oil (MO) and isopropyl myristate (IPM)) and compared with values from water and propylene glycol (PG)-water solutions. Solvent uptake and changes in stratum corneum infrared spectroscopy and multiphoton microscopy imaging were also investigated.
Results: Maximum fluxes for MO and water were similar but IPM has a higher value for more polar phenols due to a higher diffusivity and PG-water had a higher flux due to higher solubility in the stratum corneum. Whereas maximum flux for various phenols was directly related to solubility in the stratum corneum independent of vehicle, increasing phenol lipophilicity increased and decreased permeability coefficient for aqueous solvents and lipophilic solvents, respectively.
Conclusion: The maximum fluxes for phenols with a similar molecular size and varying lipophilicity were comparable between water and MO vehicles but higher for IPM and PG-water mixtures.
Keyword Diffusivity
Lipophilic vehicle
Maximum flux
Permeability Coefficient
Solubility in the stratum corneum
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 25 August 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
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