Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions

Leerberg, Joanne M. and Yap, Alpha S.K. (2013) Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions. Protoplasma, 250 4: 817-829. doi:10.1007/s00709-012-0475-6

Author Leerberg, Joanne M.
Yap, Alpha S.K.
Title Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions
Journal name Protoplasma   Check publisher's open access policy
ISSN 0033-183X
Publication date 2013-08-01
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s00709-012-0475-6
Open Access Status Not Open Access
Volume 250
Issue 4
Start page 817
End page 829
Total pages 13
Place of publication Vienna, Austria
Publisher Springer Wien
Language eng
Formatted abstract
Cell adhesion junctions characteristically arise from the cooperative integration of adhesion receptors, cell signalling pathways and the cytoskeleton. This is exemplified by cell–cell interactions mediated by classical cadherin adhesion receptors. These junctions are sites where cadherin adhesion systems functionally couple to the dynamic actin cytoskeleton, a process that entails physical interactions with many actin regulators and regulation by cell signalling pathways. Such integration implies a potential role for molecules that may stand at the interface between adhesion, signalling and the cytoskeleton. One such candidate is the cortical scaffolding protein, vinculin, which is a component of both cell–cell and cell–matrix adhesions. While its contribution to integrin-based adhesions has been extensively studied, less is known about how vinculin contributes to cell–cell adhesions. A major recent advance has come with the realisation that cadherin adhesions are active mechanical structures, where cadherin serves as part of a mechanotransduction pathway by which junctions sense and elicit cellular responses to mechanical stimuli. Vinculin has emerged as an important element in cadherin mechanotransduction, a perspective that illuminates its role in cell–cell interactions. We now review its role as a cortical scaffold and its role in cadherin mechanotransduction.
Keyword Cadherin
Adherens junction
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 631377
Institutional Status UQ
Additional Notes Published online 29 December 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Tue, 22 Jan 2013, 00:10:30 EST by Susan Allen on behalf of Institute for Molecular Bioscience