A new family of cystine knot peptides from the seeds of Momordica cochinchinensis

Chan, Lai Yue, He, Wenjun, Tan, Ninghua, Zeng, Guangzhi, Craik, David J. and Daly, Norelle L. (2013) A new family of cystine knot peptides from the seeds of Momordica cochinchinensis. Peptides, 39 1: 29-35. doi:10.1016/j.peptides.2012.09.018


Author Chan, Lai Yue
He, Wenjun
Tan, Ninghua
Zeng, Guangzhi
Craik, David J.
Daly, Norelle L.
Title A new family of cystine knot peptides from the seeds of Momordica cochinchinensis
Formatted title
A new family of cystine knot peptides from the seeds of Momordica cochinchinensis
Journal name Peptides   Check publisher's open access policy
ISSN 0196-9781
1873-5169
Publication date 2013-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.peptides.2012.09.018
Open Access Status Not Open Access
Volume 39
Issue 1
Start page 29
End page 35
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
Momordica cochinchinensis, a Cucurbitaceae plant commonly found in Southeast Asia, has the unusual property of containing both acyclic and backbone-cyclized trypsin inhibitors with inhibitor cystine knot (ICK) motifs. In the current study we have shown that M. cochinchinensis also contains another family of acyclic ICK peptides. We recently reported two novel peptides from M. cochinchinensis but have now discovered four additional peptides (MCo-3–MCo-6) with related sequences. Together these peptides form a novel family of M. cochinchinensis ICK peptides (MCo-ICK) that do not have sequence homology with other known peptides and are not potent trypsin inhibitors. Otherwise these new peptides MCo-3 to MCo-6 were evaluated for antimalarial activity against Plasmodium falciparum, and cytotoxic activity against the cancer cell line MDA-MB-231. But these peptides were not active.
Keyword Cystine knot
Peptides
MCo-3 to MCo-6
Momordica cochinchinensis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online in 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 21 Jan 2013, 20:30:32 EST by Susan Allen on behalf of Institute for Molecular Bioscience