Spider-venom peptides: structure, pharmacology, and potential for control of insect pests

King, Glenn F. and Hardy, Margaret C. (2013) Spider-venom peptides: structure, pharmacology, and potential for control of insect pests. Annual Review of Entomology, 58 475-496. doi:10.1146/annurev-ento-120811-153650


Author King, Glenn F.
Hardy, Margaret C.
Title Spider-venom peptides: structure, pharmacology, and potential for control of insect pests
Journal name Annual Review of Entomology   Check publisher's open access policy
ISSN 0066-4170
1545-4487
Publication date 2013-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1146/annurev-ento-120811-153650
Volume 58
Start page 475
End page 496
Total pages 22
Place of publication Palo Alto, CA, United States
Publisher Annual Reviews
Collection year 2013
Language eng
Abstract Spider venoms are an incredibly rich source of disulfide-rich insecticidal peptides that have been tuned over millions of years to target a wide range of receptors and ion channels in the insect nervous system. These peptides can act individually, or as part of larger toxin cabals, to rapidly immobilize envenomated prey owing to their debilitating effects on nervous system function. Most of these peptides contain a unique arrangement of disulfide bonds that provides them with extreme resistance to proteases. As a result, these peptides are highly stable in the insect gut and hemolymph and many of them are orally active. Thus, spider-venom peptides can be used as stand-alone bioinsecticides, or transgenes encoding these peptides can be used to engineer insect-resistant crops or enhanced entomopathogens. We critically review the potential of spider-venom peptides to control insect pests and highlight their advantages and disadvantages compared with conventional chemical insecticides.
Keyword Bioinsecticide
Insecticidal peptide
Insect nervous system
Inhibitor cystine knot
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online as a Review in Advance on September 27, 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 102 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 110 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 21 Jan 2013, 19:09:42 EST by Susan Allen on behalf of Institute for Molecular Bioscience