Metabolic responses of the South American ornate horned frog (Ceratophrys ornata) to estivation

Groom, Derrick J. E., Kuchel, Louise and Richards, Jeffrey G. (2013) Metabolic responses of the South American ornate horned frog (Ceratophrys ornata) to estivation. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology, 164 1: 2-9. doi:10.1016/j.cbpb.2012.08.001

Author Groom, Derrick J. E.
Kuchel, Louise
Richards, Jeffrey G.
Title Metabolic responses of the South American ornate horned frog (Ceratophrys ornata) to estivation
Journal name Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology   Check publisher's open access policy
ISSN 1096-4959
Publication date 2013-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.cbpb.2012.08.001
Volume 164
Issue 1
Start page 2
End page 9
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract We examined the metabolic responses of the South American frog, Ceratophrys ornata, to laboratory-induced estivation. Whole-animal and mass-specific oxygen consumption rate (VO2) did not change during fasting or 56 days of estivation, despite observing significant decreases in body mass. The maintenance of mass-specific metabolic rate at routine levels during estivation suggests that metabolic rate suppression is not a major response to estivation in this species. There was a significant decline in liver glycogen and a loss of adipose tissue mass during estivation, suggesting that both carbohydrate and lipid pathways are used to fuel metabolism during estivation. The activity of pyruvate dehydrogenase, an important regulator of carbohydrate oxidation, and carnitine palmitoyltransferase and 3-hydroxyacyl-CoA dehydrogenase, regulators of lipid oxidation, showed no significant change in activity in liver, heart, and muscle between estivating and active frogs. There was an increase in plasma osmolality, which is characteristic of estivating animals. Overall, our metabolic analysis of estivation in C. ornata indicates that this species does not employ a dramatic suppression metabolic rate to survive dehydration stress and that both endogenous carbohydrates and lipids are used as metabolic fuels.
Keyword Estivation
Carbohydrate metabolism
Lipid metabolism
Metabolic suppression
Oxygen consumption
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 7 August 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
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