Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study

Lewis, Sarah J., Zuccolo, Luisa, Davey Smith, George, Macleod, John, Rodriguez, Santiago, Draper, Elizabeth S., Barrow, Margaret, Alati, Rosa, Sayal, Kapil, Ring, Susan, Golding, Jean and Gray, Ron (2012) Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study. PLoS One, 7 11: e49407.1-e49407.8. doi:10.1371/journal.pone.0049407


Author Lewis, Sarah J.
Zuccolo, Luisa
Davey Smith, George
Macleod, John
Rodriguez, Santiago
Draper, Elizabeth S.
Barrow, Margaret
Alati, Rosa
Sayal, Kapil
Ring, Susan
Golding, Jean
Gray, Ron
Title Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2012-11-01
Year available 2012
Sub-type Article (original research)
DOI 10.1371/journal.pone.0049407
Open Access Status DOI
Volume 7
Issue 11
Start page e49407.1
End page e49407.8
Total pages 8
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract Whether susceptible people develop both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) or one type exclusively during life is unknown. We investigated this in an Australian community cohort of 1,191 adults aged 25-75 years by recording all new BCCs and SCCs for 16 years in people with no previous keratinocyte cancer. Among those who developed multiple skin cancers, age- and sex-specific incidence rates per 100,000 were calculated for those who developed BCC exclusively, SCC exclusively, or BCC and SCC. Corresponding relative risks (and 95% confidence intervals) were estimated by Poisson regression. During follow-up, 116 people developed multiple keratinocyte cancers: 65 (56%) developed BCC exclusively (range 2-8 per person); 18 (16%) developed SCC exclusively (2-5 per person); and 28% developed both types. Of the 116, 88 had a BCC first, of whom 74% subsequently developed only BCCs, and 28 had SCC first, of whom 64% subsequently developed only SCCs. Incidence rates did not differ by sex in the BCC-only, SCC-only, or mixed groups, but they increased significantly with age especially in the SCC-only group. These findings suggest that the majority of people are prone to develop one type rather than a mix of keratinocyte cancers.
Formatted abstract
Background: Observational studies have generated conflicting evidence on the effects of moderate maternal alcohol consumption during pregnancy on offspring cognition mainly reflecting problems of confounding. Among mothers who drink during pregnancy fetal alcohol exposure is influenced not only by mother’s intake but also by genetic variants carried by both the mother and the fetus. Associations between children’s cognitive function and both maternal and child genotype at these loci can shed light on the effects of maternal alcohol consumption on offspring cognitive development.
Methods:
We used a large population based study of women recruited during pregnancy to determine whether genetic variants in alcohol metabolising genes in this cohort of women and their children were related to the child’s cognitive score (measured by the Weschler Intelligence Scale) at age 8.
Findings: We found that four genetic variants in alcohol metabolising genes in 4167 children were strongly related to lower IQ at age 8, as was a risk allele score based on these 4 variants. This effect was only seen amongst the offspring of mothers who were moderate drinkers (1–6 units alcohol per week during pregnancy (per allele effect estimates were −1.80 (95% CI = −2.63 to −0.97) p = 0.00002, with no effect among children whose mothers abstained during pregnancy (0.16 (95%CI = −1.05 to 1.36) p = 0.80), p-value for interaction = 0.009). A further genetic variant associated with alcohol metabolism in mothers was associated with their child’s IQ, but again only among mothers who drank during pregnancy.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
MULTIDISCIPLINARY SCIENCES
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 89912
Institutional Status UQ
Additional Notes Article number e49407.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
 
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Created: Wed, 16 Jan 2013, 20:13:05 EST by Geraldine Fitzgerald on behalf of School of Public Health