Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Tsoi, Lam C., Spain, Sarah L., Knight, Jo, Ellinghaus, Eva, Stuart, Philip E., Capon, Francesca, Ding, Jun, Li, Yanming, Tejasvi, Trilokraj, Gudjonsson, Johann E., Kang, Hyun M., Allen, Michael H., McManus, Ross, Novelli, Giuseppe, Samuelsson, Lena, Schalkwijk, Joost, Stahle, Mona, Burden, A. David, Smith, Catherine H., Cork, Michael J., Estivill, Xavier, Bowcock, Anne M., Krueger, Gerald G., Weger, Wolfgang, Worthington, Jane, Tazi-Ahnini, Rachid, Nestle, Frank O., Hayday, Adrian, Hoffmann, Per, Winkelmann, Juliane, Wijmenga, Cisca, Langford, Cordelia, Edkins, Sarah, Andrews, Robert, Blackburn, Hannah, Strange, Amy, Band, Gavin, Pearson, Richard D., Vukcevic, Damjan, Spencer, Chris C. A., Deloukas, Panos, Mrowietz, Ulrich, Schreiber, Stefan, Weidinger, Stephan, Koks, Sulev, Kingo, Kuelli, Esko, Tonu, Metspalu, Andres, Lim, Henry W., Voorhees, John J., Weichenthal, Michael, Wichmann, H. Erich, Chandran, Vinod, Rosen, Cheryl F., Rahman, Proton, Gladman, Dafna D., Griffiths, Christopher E. M., Reis, Andre, Kere, Juha, Nair, Rajan P., Franke, Andre, Barker, Jonathan N. W. N., Abecasis, Goncalo R., Elder, James T., Trembath, Richard C., Duffin, Kristina Callis, Helms, Cindy, Goldgar, David, Li, Yun, Paschall, Justin, Malloy, Mary J., Pullinger, Clive R., Kane, John P., Gardner, Jennifer, Perlmutter, Amy, Miner, Andrew, Feng, Bing Jian, Hiremagalore, Ravi, Ike, Robert W., Christophers, Enno, Henseler, Tilo, Ruether, Andreas, Schrodi, Steven J., Prahalad, Sampath, Guthery, Stephen L., Fischer, Judith, Liao, Wilson, Kwok, Pui, Menter, Alan, Lathrop, G. Mark, Wise, C., Begovich, Ann B., Onoufriadis, Alexandros, Weale, Michael E., Hofer, Angelika, Salmhofer, Wolfgang, Wolf, Peter, Kainu, Kati, Saarialho-Kere, Ulpu, Suomela, Sari, Badorf, Petra, Hueffmeier, Ulrike, Kurrat, Werner, Kuester, Wolfgang, Lascorz, Jesus, Moessner, Rotraut, Schuermeier-Horst, Funda, Staender, Markward, Traupe, Heiko, Bergboer, Judith G. M., den Heijer, Martin, van de Kerkhof, Peter C., Zeeuwen, Patrick L. J. M., Barnes, Louise, Campbell, Linda E., Cusack, Caitriona, Coleman, Ciara, Conroy, Judith, Ennis, Sean, Fitzgerald, Oliver, Gallagher, Phil, Irvine, Alan D., Kirby, Brian, Markham, Trevor, McLean, W. H. Irwin, McPartlin, Joe, Rogers, Sarah F., Ryan, Anthony W., Zawirska, Agnieszka, Giardina, Emiliano, Lepre, Tiziana, Perricone, Carlo, Martin-Ezquerra, Gemma, Pujol, Ramon M., Riveira-Munoz, Eva, Inerot, Annica, Naluai, Asa T., Mallbris, Lotus, Wolk, Katarina, Leman, Joyce, Barton, Anne, Warren, Richard B., Young, Helen S., Ricano-Ponce, Isis, Trynka, Gosia, Pellett, Fawnda J., Henschel, Andrew, Aurand, Marin, Bebo, Bruce, Gieger, Christian, Illig, Thomas, Moebus, Susanne, Joeckel, Karl-Heinz, Erbe, Raimund, Donnelly, Peter, Peltonen, Leena, Blackwell, Jenefer M., Bramon, Elvira, Brown, Matthew A., Casas, Juan P., Corvin, Aiden, Craddock, Nicholas, Duncanson, Audrey, Jankowski, Janusz, Markus, Hugh S., Mathew, Christopher G., McCarthy, Mark I., Palmer, Colin N. A., Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J., Samani, Nilesh, Viswanathan, Ananth C., Wood, Nicholas W., Bellenguez, Celine, Freeman, Colin, Hellenthal, Garrett, Giannoulatou, Eleni, Pirinen, Matti, Su, Zhan, Hunt, Sarah E., Gwilliam, Rhian, Bumpstead, Suzannah J., Dronov, Serge, Gillman, Matthew, Gray, Emma, Hammond, Naomi, Jayakumar, Alagurevathi, McCann, Owen T., Liddle, Jennifer, Perez, Marc L., Potter, Simon C., Ravindrarajah, Radhi, Ricketts, Michelle, Waller, Matthew, Weston, Paul, Widaa, Sara and Whittaker, Pamela (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics, 44 12: 1341-1348. doi:10.1038/ng.2467


Author Tsoi, Lam C.
Spain, Sarah L.
Knight, Jo
Ellinghaus, Eva
Stuart, Philip E.
Capon, Francesca
Ding, Jun
Li, Yanming
Tejasvi, Trilokraj
Gudjonsson, Johann E.
Kang, Hyun M.
Allen, Michael H.
McManus, Ross
Novelli, Giuseppe
Samuelsson, Lena
Schalkwijk, Joost
Stahle, Mona
Burden, A. David
Smith, Catherine H.
Cork, Michael J.
Estivill, Xavier
Bowcock, Anne M.
Krueger, Gerald G.
Weger, Wolfgang
Worthington, Jane
Tazi-Ahnini, Rachid
Nestle, Frank O.
Hayday, Adrian
Hoffmann, Per
Winkelmann, Juliane
Wijmenga, Cisca
Langford, Cordelia
Edkins, Sarah
Andrews, Robert
Blackburn, Hannah
Strange, Amy
Band, Gavin
Pearson, Richard D.
Vukcevic, Damjan
Spencer, Chris C. A.
Deloukas, Panos
Mrowietz, Ulrich
Schreiber, Stefan
Weidinger, Stephan
Koks, Sulev
Kingo, Kuelli
Esko, Tonu
Metspalu, Andres
Lim, Henry W.
Voorhees, John J.
Weichenthal, Michael
Wichmann, H. Erich
Chandran, Vinod
Rosen, Cheryl F.
Rahman, Proton
Gladman, Dafna D.
Griffiths, Christopher E. M.
Reis, Andre
Kere, Juha
Nair, Rajan P.
Franke, Andre
Barker, Jonathan N. W. N.
Abecasis, Goncalo R.
Elder, James T.
Trembath, Richard C.
Duffin, Kristina Callis
Helms, Cindy
Goldgar, David
Li, Yun
Paschall, Justin
Malloy, Mary J.
Pullinger, Clive R.
Kane, John P.
Gardner, Jennifer
Perlmutter, Amy
Miner, Andrew
Feng, Bing Jian
Hiremagalore, Ravi
Ike, Robert W.
Christophers, Enno
Henseler, Tilo
Ruether, Andreas
Schrodi, Steven J.
Prahalad, Sampath
Guthery, Stephen L.
Fischer, Judith
Liao, Wilson
Kwok, Pui
Menter, Alan
Lathrop, G. Mark
Wise, C.
Begovich, Ann B.
Onoufriadis, Alexandros
Weale, Michael E.
Hofer, Angelika
Salmhofer, Wolfgang
Wolf, Peter
Kainu, Kati
Saarialho-Kere, Ulpu
Suomela, Sari
Badorf, Petra
Hueffmeier, Ulrike
Kurrat, Werner
Kuester, Wolfgang
Lascorz, Jesus
Moessner, Rotraut
Schuermeier-Horst, Funda
Staender, Markward
Traupe, Heiko
Bergboer, Judith G. M.
den Heijer, Martin
van de Kerkhof, Peter C.
Zeeuwen, Patrick L. J. M.
Barnes, Louise
Campbell, Linda E.
Cusack, Caitriona
Coleman, Ciara
Conroy, Judith
Ennis, Sean
Fitzgerald, Oliver
Gallagher, Phil
Irvine, Alan D.
Kirby, Brian
Markham, Trevor
McLean, W. H. Irwin
McPartlin, Joe
Rogers, Sarah F.
Ryan, Anthony W.
Zawirska, Agnieszka
Giardina, Emiliano
Lepre, Tiziana
Perricone, Carlo
Martin-Ezquerra, Gemma
Pujol, Ramon M.
Riveira-Munoz, Eva
Inerot, Annica
Naluai, Asa T.
Mallbris, Lotus
Wolk, Katarina
Leman, Joyce
Barton, Anne
Warren, Richard B.
Young, Helen S.
Ricano-Ponce, Isis
Trynka, Gosia
Pellett, Fawnda J.
Henschel, Andrew
Aurand, Marin
Bebo, Bruce
Gieger, Christian
Illig, Thomas
Moebus, Susanne
Joeckel, Karl-Heinz
Erbe, Raimund
Donnelly, Peter
Peltonen, Leena
Blackwell, Jenefer M.
Bramon, Elvira
Brown, Matthew A.
Casas, Juan P.
Corvin, Aiden
Craddock, Nicholas
Duncanson, Audrey
Jankowski, Janusz
Markus, Hugh S.
Mathew, Christopher G.
McCarthy, Mark I.
Palmer, Colin N. A.
Plomin, Robert
Rautanen, Anna
Sawcer, Stephen J.
Samani, Nilesh
Viswanathan, Ananth C.
Wood, Nicholas W.
Bellenguez, Celine
Freeman, Colin
Hellenthal, Garrett
Giannoulatou, Eleni
Pirinen, Matti
Su, Zhan
Hunt, Sarah E.
Gwilliam, Rhian
Bumpstead, Suzannah J.
Dronov, Serge
Gillman, Matthew
Gray, Emma
Hammond, Naomi
Jayakumar, Alagurevathi
McCann, Owen T.
Liddle, Jennifer
Perez, Marc L.
Potter, Simon C.
Ravindrarajah, Radhi
Ricketts, Michelle
Waller, Matthew
Weston, Paul
Widaa, Sara
Whittaker, Pamela
Title Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2012-12-01
Sub-type Article (original research)
DOI 10.1038/ng.2467
Open Access Status Not Open Access
Volume 44
Issue 12
Start page 1341
End page 1348
Total pages 8
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.
Keyword Genome-Wide Association
T-Cell Development
Gene-Expression
Celiac-Disease
Th17 Differentiation
Signaling Pathways
Negative Regulator
Interferon-Gamma
Common Variants
Multiple Common
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
UQ Diamantina Institute Publications
 
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