Microscopic diffusion anisotropy in formalin fixed prostate tissue: Preliminary findings

Bourne, Roger M., Kurniawan, Nyoman, Cowin, Gary, Sved, Paul and Watson, Geoffrey (2012) Microscopic diffusion anisotropy in formalin fixed prostate tissue: Preliminary findings. Magnetic Resonance in Medicine, 68 6: 1943-1948. doi:10.1002/mrm.24179

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Author Bourne, Roger M.
Kurniawan, Nyoman
Cowin, Gary
Sved, Paul
Watson, Geoffrey
Title Microscopic diffusion anisotropy in formalin fixed prostate tissue: Preliminary findings
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 0740-3194
1522-2594
Publication date 2012-11-01
Sub-type Article (original research)
DOI 10.1002/mrm.24179
Open Access Status File (Author Post-print)
Volume 68
Issue 6
Start page 1943
End page 1948
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Diffusion tensor microimaging at 16.4 T with 40 μm isotropic voxels was used to investigate anisotropic water diffusion in prostate tissue at spatial resolution approaching the cellular scale. Nine normal glandular tissue samples were collected from the peripheral zone of six formalin fixed radical prostatectomy specimens. Fibromuscular stromal tissue exhibited microscopic diffusion anisotropy (mean  fractional anisotropy range 0.47–0.66) significantly higher (P < 0.01, Student’s t-test) than in epithelium-containing voxels (mean fractional anisotropy range 0.31–0.54) in six of the seven normal tissue samples in which both compartments could be measured. Fiber tracking demonstrated principle stromal fiber directions consistent with myocyte orientation seen on light microscopy of the same sample. Diffusion tensor microimaging may be valuable for investigation of variable results from  attempts to measure diffusion anisotropy in the prostate in vivo.
Keyword diffusion
microimaging
prostate
anisotropy
stroma
tractography
3.0 Tesla
Mr
Cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Centre for Advanced Imaging Publications
 
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