The structure of cardiac glycogen in healthy mice

Besford, Quinn A., Sullivan, Mitchell A., Zheng, Ling, Gilbert, Robert G., Stapleton, David and Gray-Weale, Angus (2012) The structure of cardiac glycogen in healthy mice. International Journal of Biological Macromolecules, 51 5: 887-891. doi:10.1016/j.ijbiomac.2012.06.037


Author Besford, Quinn A.
Sullivan, Mitchell A.
Zheng, Ling
Gilbert, Robert G.
Stapleton, David
Gray-Weale, Angus
Title The structure of cardiac glycogen in healthy mice
Journal name International Journal of Biological Macromolecules   Check publisher's open access policy
ISSN 0141-8130
1879-0003
Publication date 2012-12-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.ijbiomac.2012.06.037
Open Access Status DOI
Volume 51
Issue 5
Start page 887
End page 891
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 1315 Structural Biology
1303 Biochemistry
1312 Molecular Biology
Abstract Transmission electron micrographs of glycogen extracted from healthy mouse hearts reveal aggregate structures around 133 nm in diameter. These structures are similar to, but on average somewhat smaller than, the alpha-particles of glycogen found in mammalian liver. Like the larger liver glycogens, these new particles in cardiac tissue appear to be aggregates of beta-particles. Free beta-particles are also present in liver, and are the only type of particle seen in skeletal muscle. They have diameters from 20 to 50 nm. We discuss the number distributions of glycogen particle diameters and the implications for the structure-function relationship of glycogens in these tissues. We point out the possible implications for the study of glycogen storage diseases, and of non-insulin dependent diabetes mellitus. (C) 2012 Elsevier B.V. All rights reserved.
Formatted abstract
Transmission electron micrographs of glycogen extracted from healthy mouse hearts reveal aggregate structures around 133. nm in diameter. These structures are similar to, but on average somewhat smaller than, the α-particles of glycogen found in mammalian liver. Like the larger liver glycogens, these new particles in cardiac tissue appear to be aggregates of β-particles. Free β-particles are also present in liver, and are the only type of particle seen in skeletal muscle. They have diameters from 20 to 50. nm. We discuss the number distributions of glycogen particle diameters and the implications for the structure-function relationship of glycogens in these tissues. We point out the possible implications for the study of glycogen storage diseases, and of non-insulin dependent diabetes mellitus.
Keyword Glycogen
Transmission electron microscopy
Dynamic light scattering
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 7 July 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Centre for Nutrition and Food Sciences Publications
 
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