Impact of pharmacists' intervention on identification and management of drug-drug interactions in an intensive care setting

Hasan, Syed Shahzad, Lim, Kim Nai, Anwar, Mudassir, Sathvik, Belagodu Sridhar, Ahmadi, Keivan, Yuan, Adelyn Wei Li and Kamarunnesa, Mokhtar Ahmad (2012) Impact of pharmacists' intervention on identification and management of drug-drug interactions in an intensive care setting. Singapore Medical Journal, 53 8: 526-531.

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Author Hasan, Syed Shahzad
Lim, Kim Nai
Anwar, Mudassir
Sathvik, Belagodu Sridhar
Ahmadi, Keivan
Yuan, Adelyn Wei Li
Kamarunnesa, Mokhtar Ahmad
Title Impact of pharmacists' intervention on identification and management of drug-drug interactions in an intensive care setting
Journal name Singapore Medical Journal   Check publisher's open access policy
ISSN 0037-5675
Publication date 2012-08-01
Sub-type Article (original research)
Volume 53
Issue 8
Start page 526
End page 531
Total pages 6
Place of publication Singapore, Singapore
Publisher Singapore Medical Association
Language eng
Formatted abstract
Introduction The primary and secondary objectives of this study were to identify and assess the risks associated with the occurrence of drug-drug interactions (DDIs) and to determine the value of pharmacists’ interventions in the management of clinically significant DDIs, respectively.
Methods A prospective, case-control study was carried out on patients admitted to the intensive care unit (ICU), and involved a review of patients’ medication chart daily by the pharmacist and the clinical parameters. All identified DDIs were carefully analysed in order to provide recommendations on the management of clinically significant DDIs.
Results The majority of DDIs were categorised as Type-C severity level (n = 305, 75.9%). ‘Substitution’ was recommended in 34 cases of clinically significant DDIs, ‘dosage adjustment’ in 17 (4.2%) and ‘stop or avoid’ in 13 (3.2%). The number of drugs prescribed (p = 0.001, rS = 0.539) and length of ICU stay (p = 0.001, rS = 0.364) were significantly associated and positively correlated with the occurrence of DDIs. Patients with DDIs had a longer length of ICU stay than those without DDIs (9.5 days vs. 2.4 days, p = 0.001). No significant difference was found between patients aged below 50 years and those above 50 years (odds ratio 0.488, 95% confidence interval 0.166–1.434) in terms of the risk of DDIs.
Conclusion A large number of DDIs were identified in this study, but only a small number were clinically significant.Pharmacists’ participation in daily ward rounds could play an important role in the detection and management of clinically significant DDIs
Keyword Drug interaction
Identification
Intensive care
Management
Pharmacist
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Pharmacy Publications
 
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