The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis C patients

Chiou, Ya-Lin, Chen, Yi-Hui, Ke, Tiffany and Ko, Wang-Sheng (2012) The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis C patients. Clinical Biochemistry, 45 16-17: 1389-1393. doi:10.1016/j.clinbiochem.2012.06.026


Author Chiou, Ya-Lin
Chen, Yi-Hui
Ke, Tiffany
Ko, Wang-Sheng
Title The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis C patients
Journal name Clinical Biochemistry   Check publisher's open access policy
ISSN 0009-9120
1873-2933
Publication date 2012-11-01
Sub-type Article (original research)
DOI 10.1016/j.clinbiochem.2012.06.026
Open Access Status Not yet assessed
Volume 45
Issue 16-17
Start page 1389
End page 1393
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 1308 Clinical Biochemistry
Abstract Background/aim: Chronic hepatitis C (CHC) patients have higher oxidative stress and ferritin than healthy individuals. However, the level of oxidative stress in CHC patients during treatment with peginterferon alpha-2a and ribavirin is not clear. The aims of our study are to investigate changes of thiobarbituric acid reactive substances (TBARS; indicated oxidative stress), total antioxidant status (TAS) and ferritin in CHC patients during therapy and to identify the correlation of these factors and the effectiveness of therapy. Methods: Sixty CHC patients were selected and were prescribed 180. μg of peginteferon alpha-2a once a week and a daily dose of 1000 to 1200. mg ribavirin for 6. months. Throughout the treatment course, blood samples were taken to determine TBARS, TAS, and liver inflammation profiles including ferritin, aspartate transaminase (AST) and alanine transaminase (ALT). Results: The level of TBARS increased before the 12th week of therapy. Additionally, the levels of TBARS were higher in non-rapid virological response (RVR) patients compared with RVR (p<. 0.01) in baseline and therapy at the 24th week. TAS was lower during therapy than at baseline. Levels of TAS were significantly higher in sustained virological response (SVR) patients than in non-SVR (p<. 0.01) in the 4th week post-therapy. We also found a positive correlation between the level of ferritin and liver inflammation during treatment (p<. 0.01). The levels of ferritin and ALT were lower in SVR than in non-SVR patients in the 4th week of post-therapy (p<. 0.01). Conclusions: This study indicated that decreased ferritin, decreased TBARS and increased TAS status may improve the efficacy of treatment.
Formatted abstract
Background/aim: Chronic hepatitis C (CHC) patients have higher oxidative stress and ferritin than healthy individuals. However, the level of oxidative stress in CHC patients during treatment with peginterferon alpha-2a and ribavirin is not clear. The aims of our study are to investigate changes of thiobarbituric acid reactive substances (TBARS; indicated oxidative stress), total antioxidant status (TAS) and ferritin in CHC patients during therapy and to identify the correlation of these factors and the effectiveness of therapy.
Methods: Sixty CHC patients were selected and were prescribed 180 μg of peginteferon alpha-2a once a week and a daily dose of 1000 to 1200 mg ribavirin for 6 months. Throughout the treatment course, blood samples were taken to determine TBARS, TAS, and liver inflammation profiles including ferritin, aspartate transaminase (AST) and alanine transaminase (ALT).
Results: The level of TBARS increased before the 12th week of therapy. Additionally, the levels of TBARS were higher in non‐rapid virological response (RVR) patients compared with RVR (p < 0.01) in baseline and therapy at the 24th week. TAS was lower during therapy than at baseline. Levels of TAS were significantly higher in sustained virological response (SVR) patients than in non-SVR (p < 0.01) in the 4th week post-therapy. We also found a positive correlation between the level of ferritin and liver inflammation during treatment (p < 0.01). The levels of ferritin and ALT were lower in SVR than in non-SVR patients in the 4th week of post-therapy (p < 0.01).
Conclusions: This study indicated that decreased ferritin, decreased TBARS and increased TAS status may improve the efficacy of treatment.
Keyword Chronic hepatitis C
Oxidative pressure
TBARS
TAS
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
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