The role of osteoclasts and tumour-associated macrophages in osteosarcoma metastasis

Endo-Munoz, Liliana, Evdokiou, Andreas and Saunders, Nicholas A. (2012) The role of osteoclasts and tumour-associated macrophages in osteosarcoma metastasis. Biochimica et Biophysica Acta - Reviews on Cancer, 1826 2: 434-442. doi:10.1016/j.bbcan.2012.07.003


Author Endo-Munoz, Liliana
Evdokiou, Andreas
Saunders, Nicholas A.
Title The role of osteoclasts and tumour-associated macrophages in osteosarcoma metastasis
Journal name Biochimica et Biophysica Acta - Reviews on Cancer   Check publisher's open access policy
ISSN 0304-419X
Publication date 2012-12-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbcan.2012.07.003
Open Access Status DOI
Volume 1826
Issue 2
Start page 434
End page 442
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 2730 Oncology
1311 Genetics
1306 Cancer Research
Abstract Osteosarcoma (OS) is the most common primary bone tumour in the paediatric age group. Treatment-refractory pulmonary metastasis continues to be the major complication of OS, reducing the 5-year survival rate for these patients to 10-20%. The mechanisms underlying the metastatic process in OS are still unclear, but undoubtedly, a greater understanding of the factors and interactions involved in its regulation will open new and much needed opportunities for therapeutic intervention. Recent published data have identified a new role for bone-specific macrophages (osteoclasts) and tumour-associated macrophages (TAMs), in OS metastasis. In this review we discuss the contribution of TAMs and osteoclasts in the establishment and maintenance of secondary metastatic lesions, and their novel role in the prevention of metastatic disease in a primary bone cancer such as osteosarcoma.
Keyword Osteosarcoma
Metastasis
Osteoclast
Tumour-associated macrophage
Microenvironment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 27 July 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
UQ Diamantina Institute Publications
 
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