Neonatal vitamin D status and childhood peanut allergy: a pilot study

Mullins, Raymond James, Clark, Sunday, Wiley, Veronica, Eyles, Darryl and Camargo, Carlos A. (2012) Neonatal vitamin D status and childhood peanut allergy: a pilot study. Annals of Allergy, Asthma and Immunology, 109 5: 324-328. doi:10.1016/j.anai.2012.07.009

Author Mullins, Raymond James
Clark, Sunday
Wiley, Veronica
Eyles, Darryl
Camargo, Carlos A.
Title Neonatal vitamin D status and childhood peanut allergy: a pilot study
Journal name Annals of Allergy, Asthma and Immunology   Check publisher's open access policy
ISSN 1081-1206
Publication date 2012-11-01
Sub-type Article (original research)
DOI 10.1016/j.anai.2012.07.009
Open Access Status DOI
Volume 109
Issue 5
Start page 324
End page 328
Total pages 5
Place of publication New York, NY United States
Publisher Elsevier
Language eng
Subject 2723 Immunology and Allergy
2740 Pulmonary and Respiratory Medicine
Abstract Maternal vitamin D deficiency during pregnancy may influence offspring kidney health. We aimed to examine the associations of 25-hydroxyvitamin D (25(OH)D) blood levels during fetal life with kidney outcomes at school age.
Formatted abstract
Background: Although a number of factors have been proposed to explain the increase in food allergy during the last decade, the possibility that vitamin D status may play a pathogenic role has received recent attention.
Objective: To determine whether lower levels of neonatal 25-hydroxyvitamin D (25[OH]D) would be observed in children with peanut allergy compared with in population controls.
Methods: The concentration of 25(OH)D was measured from neonatal dried blood samples by liquid chromatography tandem mass spectrometry. Levels were compared between children with IgE-mediated peanut allergy younger than 72 months assessed during 2008-2011 in a specialist referral clinic in the Australian Capital Territory and population births matched by sex, birth date, and birth location. Odds ratios were calculated for the matched pairs across quintiles of 25(OH)D. Results: Neonatal 25(OH)D levels ranged from 8 to 180 nmol/L (median, 66 nmol/L; interquartile range, 46-93 nmol/L); only 4 children (3%) had levels less than 25 nmol/L, and 24 (20.9%) had levels greater than 100 nmol/L. No significant association was found between socioeconomic or clinical factors and 25(OH)D levels. Compared with the reference group (50-74.9 nmol/L), levels of 75 to 99.9 nmol/L were associated with lower risk of peanut allergy (P =.02). No further reduction was found at levels of 100 nmol/L or higher, and the risk of peanut allergy at levels less than 50 nmol/L was not significantly different from the reference group.
Conclusion: The relationship between neonatal 25(OH)D level and childhood peanut allergy was nonlinear, with slightly higher levels (75-99.9 nmol/L) associated with lower risk than those in the reference group (50-74.9 nmol/L). Vitamin D status may be one of many potential factors contributing to childhood peanut allergy pathogenesis
Keyword Blood analysis
Blood Sampling
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 648916
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 22 Nov 2012, 22:35:25 EST by Debra McMurtrie on behalf of Queensland Brain Institute