Nonlinear dendritic integration of sensory and motor input during an active sensing task

Xu, Ning-long, Harnett, Mark T., Williams, Stephen R., Huber, Daniel, O'Connor, Daniel H., Svoboda, Karel and Magee, Jeffrey C. (2012) Nonlinear dendritic integration of sensory and motor input during an active sensing task. Nature, 492 7428: 247-251. doi:10.1038/nature11601


Author Xu, Ning-long
Harnett, Mark T.
Williams, Stephen R.
Huber, Daniel
O'Connor, Daniel H.
Svoboda, Karel
Magee, Jeffrey C.
Title Nonlinear dendritic integration of sensory and motor input during an active sensing task
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 2012-11-11
Sub-type Article (original research)
DOI 10.1038/nature11601
Volume 492
Issue 7428
Start page 247
End page 251
Total pages 8
Place of publication London, United Kingdom
Publisher Nature
Language eng
Abstract Active dendrites provide neurons with powerful processing capabilities. However, little is known about the role of neuronal dendrites in behaviourally related circuit computations. Here we report that a novel global dendritic nonlinearity is involved in the integration of sensory and motor information within layer 5 pyramidal neurons during an active sensing behaviour. Layer 5 pyramidal neurons possess elaborate dendritic arborizations that receive functionally distinct inputs, each targeted to spatially separate regions. At the cellular level, coincident input from these segregated pathways initiates regenerative dendritic electrical events that produce bursts of action potential output and circuits featuring this powerful dendritic nonlinearity can implement computations based on input correlation. To examine this in vivo we recorded dendritic activity in layer 5 pyramidal neurons in the barrel cortex using two-photon calcium imaging in mice performing an object-localization task. Large-amplitude, global calcium signals were observed throughout the apical tuft dendrites when active touch occurred at particular object locations or whisker angles. Such global calcium signals are produced by dendritic plateau potentials that require both vibrissal sensory input and primary motor cortex activity. These data provide direct evidence of nonlinear dendritic processing of correlated sensory and motor information in the mammalian neocortex during active sensation.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 11 November 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 145 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 150 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 21 Nov 2012, 22:46:10 EST by Debra McMurtrie on behalf of Queensland Brain Institute