The autonomic effects of deep brain stimulation-a therapeutic opportunity

Hyam, Jonathan A., Kringelbach, Morten L., Silburn, Peter A., Aziz, Tipu Z. and Green, Alexander L. (2012) The autonomic effects of deep brain stimulation-a therapeutic opportunity. Nature Reviews Neurology, 8 7: 391-400. doi:10.1038/nrneurol.2012.100

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Author Hyam, Jonathan A.
Kringelbach, Morten L.
Silburn, Peter A.
Aziz, Tipu Z.
Green, Alexander L.
Title The autonomic effects of deep brain stimulation-a therapeutic opportunity
Journal name Nature Reviews Neurology   Check publisher's open access policy
ISSN 1759-4758
Publication date 2012-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrneurol.2012.100
Open Access Status Not yet assessed
Volume 8
Issue 7
Start page 391
End page 400
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2728 Clinical Neurology
2804 Cellular and Molecular Neuroscience
Abstract Deep brain stimulation (DBS) is an expanding field in neurosurgery and has already provided important insights into the fundamental mechanisms underlying brain function. One of the most exciting emerging applications of DBS is modulation of blood pressure, respiration and micturition through its effects on the autonomic nervous system. DBS stimulation at various sites in the central autonomic network produces rapid changes in the functioning of specific organs and physiological systems that are distinct from its therapeutic effects on central nervous motor and sensory systems. For example, DBS modulates several parameters of cardiovascular function, including heart rate, blood pressure, heart rate variability, baroreceptor sensitivity and blood pressure variability. The beneficial effects of DBS also extend to improvements in lung function. This article includes an overview of the anatomy of the central autonomic network, which consists of autonomic nervous system components in the cortex, diencephalon and brainstem that project to the spinal cord or cranial nerves. The effects of DBS on physiological functioning (particularly of the cardiovascular and respiratory systems) are discussed, and the potential for these findings to be translated into therapies for patients with autonomic diseases is examined.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
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