Hydrolytic degradation of segmented polyurethane copolymers for biomedical applications

Mondal, Subrata and Martin, Darren (2012) Hydrolytic degradation of segmented polyurethane copolymers for biomedical applications. Polymer Degradation and Stability, 97 8: 1553-1561. doi:10.1016/j.polymdegradstab.2012.04.008

Author Mondal, Subrata
Martin, Darren
Title Hydrolytic degradation of segmented polyurethane copolymers for biomedical applications
Journal name Polymer Degradation and Stability   Check publisher's open access policy
ISSN 0141-3910
Publication date 2012-08-01
Sub-type Article (original research)
DOI 10.1016/j.polymdegradstab.2012.04.008
Volume 97
Issue 8
Start page 1553
End page 1561
Total pages 9
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Abstract The hydrolytic degradation of a series of segmented polyurethane (SPU) copolymers with potential for biomedical use has been investigated. A series of polyurethane copolymers were prepared from 1,6 - diisocyanatohexane (HDI), polycaprolactone diol (PCL), 2,2 - bis(hydroxymethyl) propionic acid (DMPA) and ethylene glycol (EG). The synthesized SPUs have a low soft segment glass transition temperature, a melting temperature around 50 °C, and a significant tailorable hardness for tissue engineering applications. Tensile testing of SPU films at 37 °C in phosphate buffered saline (PBS) indicated that the Young's modulus and elongation of the polyurethane copolymers could be tailored by altering the soft segment block length. All polyurethanes demonstrated hydrolytic degradability, which was measured in PBS solution at 37 °C, and the rate of degradation of the polyurethanes could be somewhat tailored by controlling the soft segment length.
Keyword Hydrolytic degradation
Segmented polyurethane copolymer
Tissue engineering
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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