Normalized diurnal and between-day trends in illicit and legal drug loads that account for changes in population

Brewer, Alex J., Ort, Christoph, Banta-Green, Caleb J., Berset, Jean-Daniel and Field, Jennifer A. (2012) Normalized diurnal and between-day trends in illicit and legal drug loads that account for changes in population. Environmental Science and Technology, 46 15: 8305-8314. doi:10.1021/es202447r


Author Brewer, Alex J.
Ort, Christoph
Banta-Green, Caleb J.
Berset, Jean-Daniel
Field, Jennifer A.
Title Normalized diurnal and between-day trends in illicit and legal drug loads that account for changes in population
Journal name Environmental Science and Technology   Check publisher's open access policy
ISSN 0013-936X
1520-5851
Publication date 2012-08-01
Sub-type Article (original research)
DOI 10.1021/es202447r
Volume 46
Issue 15
Start page 8305
End page 8314
Total pages 10
Place of publication Washington, DC United States
Publisher American Chemical Society
Collection year 2013
Language eng
Formatted abstract
Drug concentrations in composite municipal wastewater samples and census-based estimates of population are used to derive daily loads of illicit substances that are indexed to population. However, such estimates do not provide information on the diurnal trends of substance excretion nor can they account for changes in population. To address these limitations, a series of 1 h composites created by sampling wastewater influent at 6 min intervals was collected over four consecutive days at a single wastewater treatment plant. Creatinine (a urinary indicator), caffeine, methamphetamine, benzoylecgonine (BZE), and cocaine were analyzed by liquid chromatography/tandem mass spectrometry (LC-MS/MS). Diurnal trends and between-day trends were substance specific and related to the number of estimated doses and excretory half-life. Normalization to creatinine yielded trends in substances that differed significantly from non-normalized trends by accounting for changes in population within the municipality studied. Increases in normalized substance excretion observed during early morning hours originate from individuals among the resident population of the municipality due to the absence of commuters.
Keyword Tandem mass spectrometry
Personal care products
Waste water treatment
Liquid chromatography
Quantitative assessment
Urinary creatinine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Advanced Water Management Centre Publications
 
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