RNA interference for viral infections

Blake, Stephen J., Bokhari, Fawzi F. and McMillan, Nigel A. J. (2012) RNA interference for viral infections. Current Drug Targets, 13 11: 1411-1420. doi:10.2174/138945012803530161

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Author Blake, Stephen J.
Bokhari, Fawzi F.
McMillan, Nigel A. J.
Title RNA interference for viral infections
Journal name Current Drug Targets   Check publisher's open access policy
ISSN 1389-4501
Publication date 2012-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/138945012803530161
Open Access Status Not Open Access
Volume 13
Issue 11
Start page 1411
End page 1420
Total pages 10
Place of publication Bussum, Netherlands
Publisher Bentham Science
Language eng
Abstract The treatment of viral infections has relied on pre-emptive vaccination or use of a limited range of anti-viral drugs. However, the majority of viruses have no available drugs and treatment is merely supportive. RNA interference (RNAi) offers the ability to directly and rapidly treat virus infections via the targeting of viral genes. Indeed, clinical trials have already been undertaken with promising results. Here we review the current state of the RNAi field for the treatment of viral infections such as HIV, human papillomavirus and HCV. We also review novel strategies including the concept of targeting self-genes to limit viral infection and activating the immune system for improved outcomes. Finally we examine innovative approaches being pursued at the Australian Infectious Diseases Research Centre including the use of highthroughput siRNA screens to identify new antiviral targets.
Keyword HCV
RNA interference
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
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Created: Fri, 16 Nov 2012, 00:33:58 EST by System User on behalf of UQ Diamantina Institute