Acute phase proteins in healthy and sick cats

Kann, R. K. C., Seddon, J. M., Henning, J. and Meers, J. (2012) Acute phase proteins in healthy and sick cats. Research in Veterinary Science, 93 2: 649-654. doi:10.1016/j.rvsc.2011.11.007

Author Kann, R. K. C.
Seddon, J. M.
Henning, J.
Meers, J.
Title Acute phase proteins in healthy and sick cats
Journal name Research in Veterinary Science   Check publisher's open access policy
ISSN 0034-5288
Publication date 2012-10-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.rvsc.2011.11.007
Open Access Status Not yet assessed
Volume 93
Issue 2
Start page 649
End page 654
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Abstract Serum acute phase protein concentrations are used as diagnostic, therapeutic and prognostic markers in human and, less frequently, in animal medicine. The aim of this study was to determine how the health status and signalment of the cat are associated with concentrations of acute phase proteins. Generally, medians of the positive acute phase proteins appeared to be higher in sick cats compared to healthy cats. In multivariable regression models, log-transformed serum amyloid A concentration was higher in older cats, in sick and in female cats, while log-transformed α1-acid glycoprotein and haptoglobin concentrations were higher in older cats and were associated with interactions of health status (sick/healthy) and gender (male/female). The data from healthy cats in this study contribute to the limited knowledge of normal reference ranges for this species. This study highlights the potential of acute phase proteins as diagnostic markers in sick cats, but also emphasises that the signalment of the cat needs to be taken into consideration.
Keyword Acute phase protein
Serum amyloid A
Alpha1-acid glycoprotein
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Veterinary Science Publications
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