The redox system in C. elegans, a phylogenetic approach

Johnston, Andrew D. and Ebert, Paul R. (2012) The redox system in C. elegans, a phylogenetic approach. Journal of Toxicology, 2012 546915.1-546915.20. doi:10.1155/2012/546915

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Author Johnston, Andrew D.
Ebert, Paul R.
Title The redox system in C. elegans, a phylogenetic approach
Journal name Journal of Toxicology   Check publisher's open access policy
ISSN 1687-8191
Publication date 2012-01-01
Sub-type Article (original research)
DOI 10.1155/2012/546915
Open Access Status DOI
Volume 2012
Start page 546915.1
End page 546915.20
Total pages 20
Place of publication New York, NY, United States
Publisher Hindawi
Language eng
Abstract Oxidative stress is a toxic state caused by an imbalance between the production and elimination of reactive oxygen species (ROS). ROS cause oxidative damage to cellular components such as proteins, lipids, and nucleic acids. While the role of ROS in cellular damage is frequently all that is noted, ROS are also important in redox signalling. The Redox Hypothesis" has been proposed to emphasize a dual role of ROS. This hypothesis suggests that the primary effect of changes to the redox state is modified cellular signalling rather than simply oxidative damage. In extreme cases, alteration of redox signalling can contribute to the toxicity of ROS, as well as to ageing and age-related diseases. The nematode species Caenorhabditis elegans provides an excellent model for the study of oxidative stress and redox signalling in animals. We use protein sequences from central redox systems in Homo sapiens, Drosophila melanogaster, and Saccharomyces cerevisiae to query Genbank for homologous proteins in C. elegans. We then use maximum likelihood phylogenetic analysis to compare protein families between C. elegans and the other organisms to facilitate future research into the genetics of redox biology.
Keyword Oxidative stress
Reactive oxygen species (ROS)
Redox signalling
Redox Hypothesis
Caenorhabditis elegans
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 546915

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biological Sciences Publications
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Created: Sat, 10 Nov 2012, 00:25:40 EST by Gail Walter on behalf of School of Biological Sciences