Coupling diffusion imaging with histological and gene expression analysis to examine the dynamics of cortical areas across the fetal period of human brain development

Huang, Hao, Jeon, Tina, Sedmak, Goran, Pletikos, Mihovil, Vasung, Lana, Xu, Xuming, Yarowsky, Paul, Richards, Linda J., Kostović, Ivica, Šestan, Nenad and Mori, Susumu (2013) Coupling diffusion imaging with histological and gene expression analysis to examine the dynamics of cortical areas across the fetal period of human brain development. Cerebral Cortex, 23 11: 2620-2631. doi:10.1093/cercor/bhs241


Author Huang, Hao
Jeon, Tina
Sedmak, Goran
Pletikos, Mihovil
Vasung, Lana
Xu, Xuming
Yarowsky, Paul
Richards, Linda J.
Kostović, Ivica
Šestan, Nenad
Mori, Susumu
Title Coupling diffusion imaging with histological and gene expression analysis to examine the dynamics of cortical areas across the fetal period of human brain development
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1047-3211
1460-2199
Publication date 2013-11-01
Year available 2012
Sub-type Article (original research)
DOI 10.1093/cercor/bhs241
Open Access Status Not yet assessed
Volume 23
Issue 11
Start page 2620
End page 2631
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 2805 Cognitive Neuroscience
2804 Cellular and Molecular Neuroscience
Abstract As a prominent component of the human fetal brain, the structure of the cerebral wall is characterized by its laminar organization which includes the radial glial scaffold during fetal development. Diffusion tensor imaging (DTI) is useful to quantitatively delineate the microstructure of the developing brain and to clearly identify transient fetal layers in the cerebral wall. In our study, the spatio-temporal microstructural changes in the developing human fetal cerebral wall were quantitatively characterized with high-resolution DTI data of postmortem fetal brains from 13 to 21 gestational weeks. Eleven regions of interest for each layer in the entire cerebral wall were included. Distinctive time courses of microstructural changes were revealed for 11 regions of the neocortical plate. A histological analysis was also integrated to elucidate the relationship between DTI fractional anisotropy (FA) and histology. High FA values correlated with organized radial architecture in histological image. Expression levels of 17565 genes were quantified for each of 11 regions of human fetal neocortex from 13 to 21 gestational weeks to identify transcripts showing significant correlation with FA change. These correlations suggest that the heterogeneous and regionally specific microstructural changes of the human neocortex are related to different gene expression patterns.
Keyword Development
Diffusion tensor imaging
Gene expression
Histology
Human fetal brain
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID MH092535
Institutional Status UQ
Additional Notes First published online: 28 August 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
 
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Created: Fri, 09 Nov 2012, 02:15:01 EST by Debra McMurtrie on behalf of Queensland Brain Institute