EEG in ischaemic stroke: quantitative EEG can uniquely inform (sub-)acute prognoses and clinical management

Finnigan, Simon P. and van Putten, Michel J. A. M. (2013) EEG in ischaemic stroke: quantitative EEG can uniquely inform (sub-)acute prognoses and clinical management. Clinical Neurophysiology, 124 1: 10-19. doi:10.1016/j.clinph.2012.07.003

Author Finnigan, Simon P.
van Putten, Michel J. A. M.
Title EEG in ischaemic stroke: quantitative EEG can uniquely inform (sub-)acute prognoses and clinical management
Journal name Clinical Neurophysiology   Check publisher's open access policy
ISSN 1872-8952
Publication date 2013-07-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.clinph.2012.07.003
Open Access Status Not Open Access
Volume 124
Issue 1
Start page 10
End page 19
Total pages 10
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier Ireland
Language eng
Abstract Investigations of (sub-)acute ischaemic stroke (IS) employing quantitative electroencephalographic (QEEG) methods, in concert with other assessments, are reviewed. Numerous outcomes from hundreds of patients collectively indicate that (sub-)acute QEEG indices from standard systems can uniquely inform clinical management, particularly prognostication of outcomes from IS. Two classes of QEEG indices have proven particularly informative. The first quantifies the power of abnormal, slow activity relative to that of faster activity and the second, interhemispheric voltage asymmetry (broadband). Both have been identified as statistically significant predictors of outcomes assessed (via routine clinical scales) in the weeks and months following IS. Furthermore both have demonstrated higher predictive value than concomitant neurological assessments and scales, and to improve upon outcome prediction afforded by neuroimaging alone. These indices also may continuously provide unique, real-time insights into the efficacy of thrombolytic therapy, prior to clinical changes. Two key applications of QEEG which should prove valuable for future clinical management of IS are: (1) continuous, acute monitoring to inform about the efficacy of thrombolysis and decisions about potential additional interventions, and; (2) brief, subacute recording to inform outcome prognostication and clinical decisions about, for example, rehabilitation strategies. Ongoing research and technological developments will continue to facilitate clinical translation of QEEG investigations reviewed herein.
Keyword Acute stroke
Quantitative elecoencephalography
Stroke outcomes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 2 August 2012 In Press, Corrected Proof

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
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Created: Mon, 05 Nov 2012, 23:22:46 EST by Roheen Gill on behalf of UQ Centre for Clinical Research