Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding

Verweij, Karin J. H., Yang, Jian, Lahti, Jari, Veijola, Juha, Hintsanen, Mirka, Pulkki-Raback, Laura, Heinonen, Kati, Pouta, Anneli, Pesonen, Anu-Katriina, Widen, Elisabeth, Taanila, Anja, Isohanni, Matti, Miettunen, Jouko, Palotie, Aarno, Penke, Lars, Service, Susan K., Heath, Andrew C., Montgomery, Grant W., Raitakari, Olli, Kahonen, Mika, Viikari, Jorma, Raikkonen, Katri, Eriksson, Johan G., Keltikangas-Jarvinen, Liisa, Lehtimaki, Terho, Martin, Nicholas G., Jarvelin, Marjo-Riitta, Visscher, Peter M., Keller, Matthew C. and Zietsch, Brendan P. (2012) Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding. Evolution, 66 10: 3238-3251. doi:10.1111/j.1558-5646.2012.01679.x

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Author Verweij, Karin J. H.
Yang, Jian
Lahti, Jari
Veijola, Juha
Hintsanen, Mirka
Pulkki-Raback, Laura
Heinonen, Kati
Pouta, Anneli
Pesonen, Anu-Katriina
Widen, Elisabeth
Taanila, Anja
Isohanni, Matti
Miettunen, Jouko
Palotie, Aarno
Penke, Lars
Service, Susan K.
Heath, Andrew C.
Montgomery, Grant W.
Raitakari, Olli
Kahonen, Mika
Viikari, Jorma
Raikkonen, Katri
Eriksson, Johan G.
Keltikangas-Jarvinen, Liisa
Lehtimaki, Terho
Martin, Nicholas G.
Jarvelin, Marjo-Riitta
Visscher, Peter M.
Keller, Matthew C.
Zietsch, Brendan P.
Title Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding
Journal name Evolution   Check publisher's open access policy
ISSN 0014-3820
1558-5646
Publication date 2012-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1558-5646.2012.01679.x
Open Access Status File (Author Post-print)
Volume 66
Issue 10
Start page 3238
End page 3251
Total pages 14
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2013
Language eng
Abstract Personality traits are basic dimensions of behavioral variation, and twin, family, and adoption studies show that around 30% of the between-individual variation is due to genetic variation. There is rapidly growing interest in understanding the evolutionary basis of this genetic variation. Several evolutionary mechanisms could explain how genetic variation is maintained in traits, and each of these makes predictions in terms of the relative contribution of rare and common genetic variants to personality variation, the magnitude of nonadditive genetic influences, and whether personality is affected by inbreeding. Using genome-wide single nucleotide polymorphism (SNP) data from > 8000 individuals, we estimated that little variation in the Cloninger personality dimensions (7.2% on average) is due to the combined effect of common, additive genetic variants across the genome, suggesting that most heritable variation in personality is due to rare variant effects and/or a combination of dominance and epistasis. Furthermore, higher levels of inbreeding were associated with less socially desirable personality trait levels in three of the four personality dimensions. These findings are consistent with genetic variation in personality traits having been maintained by mutation–selection balance.
Keyword Antagonistic pleiotropy
Balancing selection
Behavioral syndromes
Correlational selection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Psychology Publications
 
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