The laminar cortex model: a new continuum cortex model incorporating laminar architecture

Du, Jiaxin, Vegh, Viktor and Reutens, David C. (2012) The laminar cortex model: a new continuum cortex model incorporating laminar architecture. PLoS Computational Biology, 8 10: e1002733.1-e1002733.9. doi:10.1371/journal.pcbi.1002733

Author Du, Jiaxin
Vegh, Viktor
Reutens, David C.
Title The laminar cortex model: a new continuum cortex model incorporating laminar architecture
Journal name PLoS Computational Biology   Check publisher's open access policy
ISSN 1553-734X
Publication date 2012-10-01
Sub-type Article (original research)
DOI 10.1371/journal.pcbi.1002733
Open Access Status DOI
Volume 8
Issue 10
Start page e1002733.1
End page e1002733.9
Total pages 9
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Local field potentials (LFPs) are widely used to study the function of local networks in the brain. They are also closely correlated with the blood-oxygen-level-dependent signal, the predominant contrast mechanism in functional magnetic resonance imaging. We developed a new laminar cortex model (LCM) to simulate the amplitude and frequency of LFPs. Our model combines the laminar architecture of the cerebral cortex and multiple continuum models to simulate the collective activity of cortical neurons. The five cortical layers (layer I, II/III, IV, V, and VI) are simulated as separate continuum models between which there are synaptic connections. The LCM was used to simulate the dynamics of the visual cortex under different conditions of visual stimulation. LFPs are reported for two kinds of visual stimulation: general visual stimulation and intermittent light stimulation. The power spectra of LFPs were calculated and compared with existing empirical data. The LCM was able to produce spontaneous LFPs exhibiting frequency-inverse (1/ƒ) power spectrum behaviour. Laminar profiles of current source density showed similarities to experimental data. General stimulation enhanced the oscillation of LFPs corresponding to gamma frequencies. During simulated intermittent light stimulation, the LCM captured the fundamental as well as high order harmonics as previously reported. The power spectrum expected with a reduction in layer IV neurons, often observed with focal cortical dysplasias associated with epilepsy was also simulated.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 31 Oct 2012, 02:18:29 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging