Evolutionary spread and recombination of porcine endogenous retroviruses in the Suiformes

Niebert, Marcus and Tonjes, Ralf R. (2005) Evolutionary spread and recombination of porcine endogenous retroviruses in the Suiformes. Journal of Virology, 79 1: 649-654. doi:10.1128/JVI.79.1.649-654.2005


Author Niebert, Marcus
Tonjes, Ralf R.
Title Evolutionary spread and recombination of porcine endogenous retroviruses in the Suiformes
Formatted title
Evolutionary spread and recombination of porcine endogenous retroviruses in the Suiformes
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2005-01-01
Year available 2005
Sub-type Article (original research)
DOI 10.1128/JVI.79.1.649-654.2005
Open Access Status DOI
Volume 79
Issue 1
Start page 649
End page 654
Total pages 6
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
Different Suiformes with increasing phylogenetic distance to the common pig (Sus scrofa) were assayed for the presence of porcine endogenous retroviruses (PERV) in general (pol gene), while the distribution of long terminal repeat (LTR) types (with or without repeats in U3) and env genes (classes A, B, and C) were determined in detail. PERV was not detectable in the most distantly related species, while classes PERV-A and PERV-B are present in Suiformes originating in the Pliocene epoch, and class PERV-C was detectable only in S. scrofa and in closely related species originating in the Holocene epoch. This distribution pattern of PERV classes is in line with our previous study on the age of PERV (45) and suggests an African origin of about 7.5 million years ago (MYA) and a gradual spread of PERV through the Suiformes. It seems likely that PERV-C originated more recently (1.5 to 3.5 MYA) by recombination with a homologue of unknown descent, while the origin of the repeatless LTR was a separate event approximately 3.5 MYA.
Keyword Murine leukemia-virus
Long terminal repeats
12S ribosomal-Rna
Human-cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 30 Oct 2012, 23:54:12 EST by Venerable Andrew Heath on behalf of Aust Institute for Bioengineering & Nanotechnology