The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans

Lu, Kristy, Gray, Marcus A., Oliver, Chris, Liley, David T., Harrison, Ben J., Bartholomeusz, Cali F., Phan, K. Luan and Nathan, Pradeep J. (2004) The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Human Psychopharmacology, 19 7: 457-465. doi:10.1002/hup.611

Author Lu, Kristy
Gray, Marcus A.
Oliver, Chris
Liley, David T.
Harrison, Ben J.
Bartholomeusz, Cali F.
Phan, K. Luan
Nathan, Pradeep J.
Title The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans
Journal name Human Psychopharmacology   Check publisher's open access policy
ISSN 0885-6222
Publication date 2004-10-01
Year available 2004
Sub-type Article (original research)
DOI 10.1002/hup.611
Open Access Status Not yet assessed
Volume 19
Issue 7
Start page 457
End page 465
Total pages 9
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract L-Theanine (δ-glutamylethylamide) is one of the predominant amino acids ordinarily found in green tea, and historically has been used as a relaxing agent. The current study examined the acute effects of L-theanine in comparison with a standard benzodiazepine anxiolytic, alprazolam and placebo on behavioural measures of anxiety in healthy human subjects using the model of anticipatory anxiety (AA). Sixteen healthy volunteers received alprazolam (1 mg), L-theanine (200 mg) or placebo in a double-blind placebo-controlled repeated measures design. The acute effects of alprazolam and L-theanine were assessed under a relaxed and experimentally induced anxiety condition. Subjective self-reports of anxiety including BAI, VAMS, STAI state anxiety, were obtained during both task conditions at pre- and post-drug administrations. The results showed some evidence for relaxing effects of L-theanine during the baseline condition on the tranquil–troubled subscale of the VAMS. Alprazolam did not exert any anxiolytic effects in comparison with the placebo on any of the measures during the relaxed state. Neither L-theanine nor alprazalam had any significant anxiolytic effects during the experimentally induced anxiety state. The findings suggest that while L-theanine may have some relaxing effects under resting conditions, neither L-theanine not alprazolam demonstrate any acute anxiolytic effects under conditions of increased anxiety in the AA model.
Keyword L-theanine
Anticipatory anxiety
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
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Created: Tue, 30 Oct 2012, 21:38:59 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging