The neuropharmacology of Ltheanine( N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent

Nathan, Pradeep J., Lu, Kristy, Gray, M. and Oliver, C. (2006) The neuropharmacology of Ltheanine( N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. Journal of Herbal Pharmacotherapy, 6 2: 21-30. doi:10.1300/J157v06n02_02


Author Nathan, Pradeep J.
Lu, Kristy
Gray, M.
Oliver, C.
Title The neuropharmacology of Ltheanine( N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent
Journal name Journal of Herbal Pharmacotherapy   Check publisher's open access policy
ISSN 1522-8940
1522-9106
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1300/J157v06n02_02
Open Access Status Not yet assessed
Volume 6
Issue 2
Start page 21
End page 30
Total pages 10
Place of publication Binghamton, NY, United States
Publisher Haworth Herbal Press
Language eng
Abstract L-theanine (N-ethyl-L-glutamine) or theanine is a major amino acid uniquely found in green tea. L-theanine has been historically reported as a relaxing agent, prompting scientific research on its pharmacology. Animal neurochemistry studies suggest that L-theanine increases brain serotonin, dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors. In addition has been shown to exert neuroprotective effects in animal models possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors. Behavioural studies in animals suggest improvement in learning and memory. Overall, L-theanine displays a neuropharmacology suggestive of a possible neuroprotective and cognitive enhancing agent and warrants further investigation in animals and humans.
Keyword Cerebral infarct
Cognition and anxiety
Monoamines
Neuropharmacology
Neuroprotection
Pharmacology
Theanine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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Created: Tue, 30 Oct 2012, 21:36:20 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging