A review of the pathology of abnormal placentae of somatic cell nuclear transfer clone pregnancies in cattle, sheep, and mice

Palmieri, C., Loi, P., Ptak, G. and Della Salda, L. (2008) A review of the pathology of abnormal placentae of somatic cell nuclear transfer clone pregnancies in cattle, sheep, and mice. Veterinary Pathology, 45 6: 865-880. doi:10.1354/vp.45-6-865


Author Palmieri, C.
Loi, P.
Ptak, G.
Della Salda, L.
Title A review of the pathology of abnormal placentae of somatic cell nuclear transfer clone pregnancies in cattle, sheep, and mice
Journal name Veterinary Pathology   Check publisher's open access policy
ISSN 0300-9858
1544-2217
Publication date 2008-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1354/vp.45-6-865
Open Access Status Not Open Access
Volume 45
Issue 6
Start page 865
End page 880
Total pages 16
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Language eng
Abstract Cloning of cattle, sheep, and mice by somatic cell nuclear transfer (SCNT) can result in apparently healthy offspring, but the probability of a successful and complete pregnancy is less than 5%. Failures of SCNT pregnancy are associated with placental abnormalities, such as placentomegaly, reduced vascularisation, hypoplasia of trophoblastic epithelium, and altered basement membrane. The pathogenesis of these changes is poorly understood, but current evidence implicates aberrant reprogramming of donor nuclei by the recipient oocyte cytoplast, resulting in epigenetic modifications of key regulatory genes essential for normal placental development. The purpose of this review is to provide an overview of the anatomic pathology of abnormal placentae of SCNT clones and to summarize current knowledge concerning underlying pathogenetic mechanisms.
Keyword DNA methylation
Mice
Nuclear reprogramming
Nuclear transfer techniques
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Veterinary Science Publications
 
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Created: Sat, 20 Oct 2012, 03:19:22 EST by Chiara Palmieri on behalf of School of Veterinary Science