RON is not a prognostic marker for resectable pancreatic cancer

Tactacan, Carole M., Chang, David K., Cowley, Mark J., Humphrey, Emily S., Wu, Jianmin, Gill, Anthony J., Chou, Angela, Nones, Katia, Grimmond, Sean M., Sutherland, Robert L., Biankin, Andrew V., Daly, Roger J. and Australian Pancreratic Genome Initiative (2012) RON is not a prognostic marker for resectable pancreatic cancer. BMC Cancer, 12 Article No.395: . doi:10.1186/1471-2407-12-395

Author Tactacan, Carole M.
Chang, David K.
Cowley, Mark J.
Humphrey, Emily S.
Wu, Jianmin
Gill, Anthony J.
Chou, Angela
Nones, Katia
Grimmond, Sean M.
Sutherland, Robert L.
Biankin, Andrew V.
Daly, Roger J.
Australian Pancreratic Genome Initiative
Title RON is not a prognostic marker for resectable pancreatic cancer
Journal name BMC Cancer   Check publisher's open access policy
ISSN 1471-2407
Publication date 2012-09-07
Year available 2012
Sub-type Article (original research)
DOI 10.1186/1471-2407-12-395
Open Access Status DOI
Volume 12
Issue Article No.395
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Background: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown.

Methods: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed.

Results: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study.

Conclusions: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.
Keyword Receptor tyrosine kinase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 12 Oct 2012, 01:01:01 EST by Susan Allen on behalf of Institute for Molecular Bioscience