Can maternal microchimeric cells influence the fetal response toward self antigens?

Leveque, Lucie and Khosrotehrani, Kiarash (2011) Can maternal microchimeric cells influence the fetal response toward self antigens?. Chimerism, 2 3: 71-77. doi:10.4161/chim.2.3.17589


Author Leveque, Lucie
Khosrotehrani, Kiarash
Title Can maternal microchimeric cells influence the fetal response toward self antigens?
Journal name Chimerism   Check publisher's open access policy
ISSN 1938-1956
1938-1964
Publication date 2011-12-12
Sub-type Article (original research)
DOI 10.4161/chim.2.3.17589
Volume 2
Issue 3
Start page 71
End page 77
Total pages 7
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Language eng
Abstract The origins of autoimmunity are still elusive despite significant advances in immunology. There is cumulative evidence that, beyond simple genetics, the maternal environment plays a critical role in the development of common autoimmune disorders, such as multiple sclerosis or diabetes. In recent years, the trafficking of maternal cells to the offspring has been clearly demonstrated. This microchimerism represents the very first immunological event in fetal life. The number of persisting maternal cells has been associated with several autoimmune disorders such as systemic sclerosis, juvenile dermatomyositis or diabetes. Though, the precise role of the maternal cells in these disorders remains unclear. Based on recent experimental work in an animal model of juvenile diabetes, we will discuss the possibility of maternal cells modifying the response of the developing fetal immunity towards self.
Keyword Maternal microchimerism
Pregnancy
Regulatory T cells
Autoimmunity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 04 Oct 2012, 20:03:13 EST by Roheen Gill on behalf of UQ Centre for Clinical Research