The angiotensin II type 2 (AT(2)) receptor: an enigmatic seven transmembrane receptor

Porrello, Enzo R., Delbridge, Lea M. D. and Thomas, Walter G. (2009) The angiotensin II type 2 (AT(2)) receptor: an enigmatic seven transmembrane receptor. Frontiers in Bioscience, 14 3: 958-972. doi:10.2741/3289


Author Porrello, Enzo R.
Delbridge, Lea M. D.
Thomas, Walter G.
Title The angiotensin II type 2 (AT(2)) receptor: an enigmatic seven transmembrane receptor
Journal name Frontiers in Bioscience   Check publisher's open access policy
ISSN 1093-9946
1093-4715
Publication date 2009-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2741/3289
Volume 14
Issue 3
Start page 958
End page 972
Total pages 15
Place of publication Albertson, NY, United States
Publisher Frontiers in Bioscience
Language eng
Formatted abstract
Angiotensin II (AngII) interacts with two receptor subtypes, AT1 and AT 2, belonging to the seven transmembrane receptor superfamily. Pharmacological investigations initially suggested that AT 2 receptors antagonize AT1 effects. Data from AT 2 receptor transgenic and knock-out mice have not been entirely consistent with this interpretation. At the cellular level, a clear mechanistic model of AT 2 transduction and signalling has yet to emerge. The AT 2 receptor displays the hallmark motifs and signature residues of a G protein-coupled receptor (GPCR), but fails to demonstrate most of the classic features of GPCR signalling. In recent years, unbiased screens for AT 2-interacting proteins have identified novel partner proteins involved in AT 2 signalling, providing new insight into the mechanisms of AT 2 action. A growing body of evidence suggests that the AT 2 receptor is constitutively active (i.e. signals without AngII). This review critically evaluates controversies surrounding physiological functions and signalling mechanisms of the AT 2 receptor, primarily in a cardiovascular context. Recent advances in the field are highlighted and findings challenging the concept that the AT 2 receptor is a conventional angiotensin receptor are considered.
Keyword Angiotensin II type 2 receptor
AT2 receptor
Angiotensin II
G protein-coupled receptor
GPCR
Signalling
Constitutive activity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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