Catalyst-free N-arylation using unactivated fluorobenzenes

Diness, Frederik and Fairlie, David (2012) Catalyst-free N-arylation using unactivated fluorobenzenes. Angewandte Chemie International Edition, 51 32: 8012-8016. doi:10.1002/anie.201202149

Author Diness, Frederik
Fairlie, David
Title Catalyst-free N-arylation using unactivated fluorobenzenes
Journal name Angewandte Chemie International Edition   Check publisher's open access policy
ISSN 1433-7851
Publication date 2012-08-06
Sub-type Article (original research)
DOI 10.1002/anie.201202149
Volume 51
Issue 32
Start page 8012
End page 8016
Total pages 5
Place of publication Weinheim, Germany
Publisher Wiley
Language eng
Formatted abstract
Caught in a 'S NAr'e: A one-step, high-yielding, catalyst-free method is described for N-arylation of azoles and indoles from unactivated monofluorobenzenes. This S NAr reaction tolerates a wide range of substituents and can also generate halogenated N-aryl products. The reaction can also be performed simultaneously with or subsequent to a copper- or palladium-catalyzed cross-coupling reaction in the same pot.
Keyword Aromatic substitution
Microwave chemistry
Nucleophilic substitution
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online 2 July 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 53 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 52 times in Scopus Article | Citations
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Created: Sat, 22 Sep 2012, 00:28:23 EST by Susan Allen on behalf of Institute for Molecular Bioscience