Maternal-fetal transmission of HBV

Bhat, Purnima (2012). Maternal-fetal transmission of HBV. In György Berencsi III (Ed.), Maternal fetal transmission of human viruses and their influence on tumorigenesis (pp. 195-222) Dordrecht, Netherlands: Springer. doi:10.1007/978-94-007-4216-1_6

Author Bhat, Purnima
Title of chapter Maternal-fetal transmission of HBV
Title of book Maternal fetal transmission of human viruses and their influence on tumorigenesis
Place of Publication Dordrecht, Netherlands
Publisher Springer
Publication Year 2012
Sub-type Research book chapter (original research)
DOI 10.1007/978-94-007-4216-1_6
Open Access Status Not yet assessed
ISBN 9789400742161
Editor György Berencsi III
Volume number 9789400742161
Chapter number 6
Start page 195
End page 222
Total pages 28
Total chapters 11
Language eng
Formatted Abstract/Summary
The human hepatitis B virus was shown to be transmitted horizontally by different ways (sexual intercourse, medical interventions, intraveneous drug abuse, tattooing, pearcing etc.).
The perinatal transmission has been recognized and accepted only after during the last three decades. The evidences indicating the existence of transplacental transmission has been proven and summarized only in this century.
The maternal-fetal transmission was shown to be influenced by the viral load, by the genetic properties of the virus and by the HLA haplotypes of the parents and the fetus.
The active immunization of the population was found to reduce the maternal-fetal transmission of HBV significantly.
The maternal-fetal transmission was shown to be reduced by caesarean section, by the chemotherapy of HBV-carrier pregnants, and by the passive- and active immunization of the newborns.
There is a real chance of the global eradication of hepatitis B virus from the human population, which is one of the major cause of the human liver cancer. The reduction of prenatal infection could be achieved by the reduction of maternal viral load using nucleoside analogues and vaccination in the future.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: Official 2013 Collection
UQ Diamantina Institute Publications
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Created: Fri, 21 Sep 2012, 20:22:23 EST by Ms Imogen Ferrier on behalf of UQ Diamantina Institute